A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division
Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubul...
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/0822bd0027864a7a9eecc223dca2b6f0 |
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oai:doaj.org-article:0822bd0027864a7a9eecc223dca2b6f02021-12-02T17:31:08ZA high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division10.1038/s41467-020-14978-72041-1723https://doaj.org/article/0822bd0027864a7a9eecc223dca2b6f02020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14978-7https://doaj.org/toc/2041-1723Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25.Lovorka StojicAaron T. L. LunPatrice MascalchiChristina ErnstAisling M. RedmondJasmin MangeiAlexis R. BarrVicky BousgouniChris BakalJohn C. MarioniDuncan T. OdomFanni GergelyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lovorka Stojic Aaron T. L. Lun Patrice Mascalchi Christina Ernst Aisling M. Redmond Jasmin Mangei Alexis R. Barr Vicky Bousgouni Chris Bakal John C. Marioni Duncan T. Odom Fanni Gergely A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| description |
Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25. |
| format |
article |
| author |
Lovorka Stojic Aaron T. L. Lun Patrice Mascalchi Christina Ernst Aisling M. Redmond Jasmin Mangei Alexis R. Barr Vicky Bousgouni Chris Bakal John C. Marioni Duncan T. Odom Fanni Gergely |
| author_facet |
Lovorka Stojic Aaron T. L. Lun Patrice Mascalchi Christina Ernst Aisling M. Redmond Jasmin Mangei Alexis R. Barr Vicky Bousgouni Chris Bakal John C. Marioni Duncan T. Odom Fanni Gergely |
| author_sort |
Lovorka Stojic |
| title |
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| title_short |
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| title_full |
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| title_fullStr |
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| title_full_unstemmed |
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division |
| title_sort |
high-content rnai screen reveals multiple roles for long noncoding rnas in cell division |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0822bd0027864a7a9eecc223dca2b6f0 |
| work_keys_str_mv |
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