Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally thought to be closely related to genetic and environmental risk factors. Although treatment options for SLE with hormones, immunosuppressants, and biologic drugs are now available, the rates of clinical respons...

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Autores principales:	Quanren Pan, Fengbiao Guo, Yanyan Huang, Aifen Li, Shuxian Chen, Jiaxuan Chen, Hua-feng Liu, Qingjun Pan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	systemic lupus erythematosus autoimmune disease gut microbiota dysbiosis extracellular vesicle miRNA mesenchymal stem cell therapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/082389f3ac1540ffa97eadf38fe8f77b
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spelling	oai:doaj.org-article:082389f3ac1540ffa97eadf38fe8f77b2021-12-03T04:46:35ZGut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies1664-322410.3389/fimmu.2021.799788https://doaj.org/article/082389f3ac1540ffa97eadf38fe8f77b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.799788/fullhttps://doaj.org/toc/1664-3224Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally thought to be closely related to genetic and environmental risk factors. Although treatment options for SLE with hormones, immunosuppressants, and biologic drugs are now available, the rates of clinical response and functional remission of these drugs are still not satisfactory. Currently, emerging evidence suggests that gut microbiota dysbiosis may play crucial roles in the occurrence and development of SLE, and manipulation of targeting the gut microbiota holds great promises for the successful treatment of SLE. The possible mechanisms of gut microbiota dysbiosis in SLE have not yet been well identified to date, although they may include molecular mimicry, impaired intestinal barrier function and leaky gut, bacterial biofilms, intestinal specific pathogen infection, gender bias, intestinal epithelial cells autophagy, and extracellular vesicles and microRNAs. Potential therapies for modulating gut microbiota in SLE include oral antibiotic therapy, fecal microbiota transplantation, glucocorticoid therapy, regulation of intestinal epithelial cells autophagy, extracellular vesicle-derived miRNA therapy, mesenchymal stem cell therapy, and vaccination. This review summarizes novel insights into the mechanisms of microbiota dysbiosis in SLE and promising therapeutic strategies, which may help improve our understanding of the pathogenesis of SLE and provide novel therapies for SLE.Quanren PanFengbiao GuoYanyan HuangAifen LiShuxian ChenJiaxuan ChenHua-feng LiuQingjun PanFrontiers Media S.A.articlesystemic lupus erythematosusautoimmune diseasegut microbiota dysbiosisextracellular vesiclemiRNAmesenchymal stem cell therapyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic lupus erythematosus autoimmune disease gut microbiota dysbiosis extracellular vesicle miRNA mesenchymal stem cell therapy Immunologic diseases. Allergy RC581-607
spellingShingle	systemic lupus erythematosus autoimmune disease gut microbiota dysbiosis extracellular vesicle miRNA mesenchymal stem cell therapy Immunologic diseases. Allergy RC581-607 Quanren Pan Fengbiao Guo Yanyan Huang Aifen Li Shuxian Chen Jiaxuan Chen Hua-feng Liu Qingjun Pan Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
description	Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally thought to be closely related to genetic and environmental risk factors. Although treatment options for SLE with hormones, immunosuppressants, and biologic drugs are now available, the rates of clinical response and functional remission of these drugs are still not satisfactory. Currently, emerging evidence suggests that gut microbiota dysbiosis may play crucial roles in the occurrence and development of SLE, and manipulation of targeting the gut microbiota holds great promises for the successful treatment of SLE. The possible mechanisms of gut microbiota dysbiosis in SLE have not yet been well identified to date, although they may include molecular mimicry, impaired intestinal barrier function and leaky gut, bacterial biofilms, intestinal specific pathogen infection, gender bias, intestinal epithelial cells autophagy, and extracellular vesicles and microRNAs. Potential therapies for modulating gut microbiota in SLE include oral antibiotic therapy, fecal microbiota transplantation, glucocorticoid therapy, regulation of intestinal epithelial cells autophagy, extracellular vesicle-derived miRNA therapy, mesenchymal stem cell therapy, and vaccination. This review summarizes novel insights into the mechanisms of microbiota dysbiosis in SLE and promising therapeutic strategies, which may help improve our understanding of the pathogenesis of SLE and provide novel therapies for SLE.
format	article
author	Quanren Pan Fengbiao Guo Yanyan Huang Aifen Li Shuxian Chen Jiaxuan Chen Hua-feng Liu Qingjun Pan
author_facet	Quanren Pan Fengbiao Guo Yanyan Huang Aifen Li Shuxian Chen Jiaxuan Chen Hua-feng Liu Qingjun Pan
author_sort	Quanren Pan
title	Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
title_short	Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
title_full	Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
title_fullStr	Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
title_full_unstemmed	Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies
title_sort	gut microbiota dysbiosis in systemic lupus erythematosus: novel insights into mechanisms and promising therapeutic strategies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/082389f3ac1540ffa97eadf38fe8f77b
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Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies

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