Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previ...

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Autores principales: Shaza B. Zaghlool, Brigitte Kühnel, Mohamed A. Elhadad, Sara Kader, Anna Halama, Gaurav Thareja, Rudolf Engelke, Hina Sarwath, Eman K. Al-Dous, Yasmin A. Mohamoud, Thomas Meitinger, Rory Wilson, Konstantin Strauch, Annette Peters, Dennis O. Mook-Kanamori, Johannes Graumann, Joel A. Malek, Christian Gieger, Melanie Waldenberger, Karsten Suhre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/0823a74153c147a29321e71963cf2a18
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Sumario:DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previously reported disease associations.

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