Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previ...

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Autores principales:	Shaza B. Zaghlool, Brigitte Kühnel, Mohamed A. Elhadad, Sara Kader, Anna Halama, Gaurav Thareja, Rudolf Engelke, Hina Sarwath, Eman K. Al-Dous, Yasmin A. Mohamoud, Thomas Meitinger, Rory Wilson, Konstantin Strauch, Annette Peters, Dennis O. Mook-Kanamori, Johannes Graumann, Joel A. Malek, Christian Gieger, Melanie Waldenberger, Karsten Suhre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0823a74153c147a29321e71963cf2a18
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spelling	oai:doaj.org-article:0823a74153c147a29321e71963cf2a182021-12-02T16:50:00ZEpigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits10.1038/s41467-019-13831-w2041-1723https://doaj.org/article/0823a74153c147a29321e71963cf2a182020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13831-whttps://doaj.org/toc/2041-1723DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previously reported disease associations.Shaza B. ZaghloolBrigitte KühnelMohamed A. ElhadadSara KaderAnna HalamaGaurav TharejaRudolf EngelkeHina SarwathEman K. Al-DousYasmin A. MohamoudThomas MeitingerRory WilsonKonstantin StrauchAnnette PetersDennis O. Mook-KanamoriJohannes GraumannJoel A. MalekChristian GiegerMelanie WaldenbergerKarsten SuhreNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaza B. Zaghlool Brigitte Kühnel Mohamed A. Elhadad Sara Kader Anna Halama Gaurav Thareja Rudolf Engelke Hina Sarwath Eman K. Al-Dous Yasmin A. Mohamoud Thomas Meitinger Rory Wilson Konstantin Strauch Annette Peters Dennis O. Mook-Kanamori Johannes Graumann Joel A. Malek Christian Gieger Melanie Waldenberger Karsten Suhre Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
description	DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previously reported disease associations.
format	article
author	Shaza B. Zaghlool Brigitte Kühnel Mohamed A. Elhadad Sara Kader Anna Halama Gaurav Thareja Rudolf Engelke Hina Sarwath Eman K. Al-Dous Yasmin A. Mohamoud Thomas Meitinger Rory Wilson Konstantin Strauch Annette Peters Dennis O. Mook-Kanamori Johannes Graumann Joel A. Malek Christian Gieger Melanie Waldenberger Karsten Suhre
author_facet	Shaza B. Zaghlool Brigitte Kühnel Mohamed A. Elhadad Sara Kader Anna Halama Gaurav Thareja Rudolf Engelke Hina Sarwath Eman K. Al-Dous Yasmin A. Mohamoud Thomas Meitinger Rory Wilson Konstantin Strauch Annette Peters Dennis O. Mook-Kanamori Johannes Graumann Joel A. Malek Christian Gieger Melanie Waldenberger Karsten Suhre
author_sort	Shaza B. Zaghlool
title	Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
title_short	Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
title_full	Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
title_fullStr	Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
title_full_unstemmed	Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
title_sort	epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0823a74153c147a29321e71963cf2a18
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Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

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