Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent

Glaucoma represents a chronic eye disease that becomes increasingly prevalent worldwide. Therapies are commonly based on the reduction of intraocular pressure (IOP). Implant devices for micro-invasive glaucoma surgery (MIGS) represent a promising therapy option in refractory cases but suffer from li...

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Autores principales:	Siewert Stefan, Großmann Swen, Brandt-Wunderlich Christoph, Dierke Ariane, Stiehm Michael, Schmitz Klaus-Peter, Sahmel Olga, Kischkel Sabine, Schmidt Wolfram, Grabow Niels, Stahnke Thomas, Guthoff Rudolf
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	glaucoma microstent fixation ansi minimally invasive glaucoma surgery micro-invasive glaucoma surgery migs Medicine R
Acceso en línea:	https://doaj.org/article/08279c51fc4b49a1903fb33ce9fbf9f3
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spelling	oai:doaj.org-article:08279c51fc4b49a1903fb33ce9fbf9f32021-12-05T14:10:42ZDevelopment of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent2364-550410.1515/cdbme-2020-3056https://doaj.org/article/08279c51fc4b49a1903fb33ce9fbf9f32020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3056https://doaj.org/toc/2364-5504Glaucoma represents a chronic eye disease that becomes increasingly prevalent worldwide. Therapies are commonly based on the reduction of intraocular pressure (IOP). Implant devices for micro-invasive glaucoma surgery (MIGS) represent a promising therapy option in refractory cases but suffer from limitations in long term efficacy or from dislocation associated complications. Our approach of an innovative drug-eluting glaucoma microstent for MIGS was presented previously. Within the current work we developed concepts and prototypes of a mechanism for the fixation of our glaucoma microstent in the region of the corneal limbus. A tripod and a haptics design of the fixation mechanism were developed and manufactured. Semifinished products were tested with regard to dimensional stability and mechanical properties according to the standard ANSI Z80.27-2014. Considering the mechanical properties of ocular target tissues, a gelatin based in vitro model for the measurement of microstent retention force was developed. Retention force testing of microstent prototypes in vitro resulted in a proof of concept for the fixation mechanism. Future studies will focus on the use of smaller fixation fibers, for example commercially available suture material, and on an overall miniaturization of the fixation mechanism enabling the use of our applicator device with a 22G x 1½” cannula.Siewert StefanGroßmann SwenBrandt-Wunderlich ChristophDierke ArianeStiehm MichaelSchmitz Klaus-PeterSahmel OlgaKischkel SabineSchmidt WolframGrabow NielsStahnke ThomasGuthoff RudolfDe Gruyterarticleglaucomamicrostentfixationansiminimally invasive glaucoma surgerymicro-invasive glaucoma surgerymigsMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 221-224 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma microstent fixation ansi minimally invasive glaucoma surgery micro-invasive glaucoma surgery migs Medicine R
spellingShingle	glaucoma microstent fixation ansi minimally invasive glaucoma surgery micro-invasive glaucoma surgery migs Medicine R Siewert Stefan Großmann Swen Brandt-Wunderlich Christoph Dierke Ariane Stiehm Michael Schmitz Klaus-Peter Sahmel Olga Kischkel Sabine Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
description	Glaucoma represents a chronic eye disease that becomes increasingly prevalent worldwide. Therapies are commonly based on the reduction of intraocular pressure (IOP). Implant devices for micro-invasive glaucoma surgery (MIGS) represent a promising therapy option in refractory cases but suffer from limitations in long term efficacy or from dislocation associated complications. Our approach of an innovative drug-eluting glaucoma microstent for MIGS was presented previously. Within the current work we developed concepts and prototypes of a mechanism for the fixation of our glaucoma microstent in the region of the corneal limbus. A tripod and a haptics design of the fixation mechanism were developed and manufactured. Semifinished products were tested with regard to dimensional stability and mechanical properties according to the standard ANSI Z80.27-2014. Considering the mechanical properties of ocular target tissues, a gelatin based in vitro model for the measurement of microstent retention force was developed. Retention force testing of microstent prototypes in vitro resulted in a proof of concept for the fixation mechanism. Future studies will focus on the use of smaller fixation fibers, for example commercially available suture material, and on an overall miniaturization of the fixation mechanism enabling the use of our applicator device with a 22G x 1½” cannula.
format	article
author	Siewert Stefan Großmann Swen Brandt-Wunderlich Christoph Dierke Ariane Stiehm Michael Schmitz Klaus-Peter Sahmel Olga Kischkel Sabine Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf
author_facet	Siewert Stefan Großmann Swen Brandt-Wunderlich Christoph Dierke Ariane Stiehm Michael Schmitz Klaus-Peter Sahmel Olga Kischkel Sabine Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf
author_sort	Siewert Stefan
title	Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
title_short	Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
title_full	Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
title_fullStr	Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
title_full_unstemmed	Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
title_sort	development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/08279c51fc4b49a1903fb33ce9fbf9f3
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Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent

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