Zinc Finger Proteins in Neuro-Related Diseases Progression

Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In...

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Autores principales:	Siyuan Bu, Yihan Lv, Yusheng Liu, Sen Qiao, Hongmei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease ischemic stroke zinc finger proteins neuro-related diseases schizophrenia epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0827e67c04ee4e35a92a758d58b807aa
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id	oai:doaj.org-article:0827e67c04ee4e35a92a758d58b807aa
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spelling	oai:doaj.org-article:0827e67c04ee4e35a92a758d58b807aa2021-11-18T09:42:30ZZinc Finger Proteins in Neuro-Related Diseases Progression1662-453X10.3389/fnins.2021.760567https://doaj.org/article/0827e67c04ee4e35a92a758d58b807aa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.760567/fullhttps://doaj.org/toc/1662-453XZinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.Siyuan BuYihan LvYusheng LiuSen QiaoHongmei WangFrontiers Media S.A.articleAlzheimer’s diseaseischemic strokezinc finger proteinsneuro-related diseasesschizophreniaepilepsyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease ischemic stroke zinc finger proteins neuro-related diseases schizophrenia epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease ischemic stroke zinc finger proteins neuro-related diseases schizophrenia epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Siyuan Bu Yihan Lv Yusheng Liu Sen Qiao Hongmei Wang Zinc Finger Proteins in Neuro-Related Diseases Progression
description	Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.
format	article
author	Siyuan Bu Yihan Lv Yusheng Liu Sen Qiao Hongmei Wang
author_facet	Siyuan Bu Yihan Lv Yusheng Liu Sen Qiao Hongmei Wang
author_sort	Siyuan Bu
title	Zinc Finger Proteins in Neuro-Related Diseases Progression
title_short	Zinc Finger Proteins in Neuro-Related Diseases Progression
title_full	Zinc Finger Proteins in Neuro-Related Diseases Progression
title_fullStr	Zinc Finger Proteins in Neuro-Related Diseases Progression
title_full_unstemmed	Zinc Finger Proteins in Neuro-Related Diseases Progression
title_sort	zinc finger proteins in neuro-related diseases progression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0827e67c04ee4e35a92a758d58b807aa
work_keys_str_mv	AT siyuanbu zincfingerproteinsinneurorelateddiseasesprogression AT yihanlv zincfingerproteinsinneurorelateddiseasesprogression AT yushengliu zincfingerproteinsinneurorelateddiseasesprogression AT senqiao zincfingerproteinsinneurorelateddiseasesprogression AT hongmeiwang zincfingerproteinsinneurorelateddiseasesprogression
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Zinc Finger Proteins in Neuro-Related Diseases Progression

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