Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation
Roberta Araujo Navarro-Xavier,1 Karina Vieira de Barros,1 Iracema Senna de Andrade,1 Zaira Palomino,2 Dulce Elena Casarini,2 Vera Lucia Flor Silveira3 1Departamento de Fisiologia, 2Departamento de Medicina, 3Departamento de Ciências Biológicas, Universidade Federal de S&atil...
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Dove Medical Press
2016
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oai:doaj.org-article:0827e6c58d494f19808a31bac4296d102021-12-02T00:17:39ZProtective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation1178-7031https://doaj.org/article/0827e6c58d494f19808a31bac4296d102016-05-01T00:00:00Zhttps://www.dovepress.com/protective-effect-of-soybean-oil--or-fish-oil-rich-diets-on-allergic-a-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Roberta Araujo Navarro-Xavier,1 Karina Vieira de Barros,1 Iracema Senna de Andrade,1 Zaira Palomino,2 Dulce Elena Casarini,2 Vera Lucia Flor Silveira3 1Departamento de Fisiologia, 2Departamento de Medicina, 3Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Diadema, São Paulo, Brazil Background: The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin [IL]-4, IL-5) and Th1 (interferon [IFN]-γ, tumor necrosis factor-α) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs. Methods: Male Wistar rats fed with soybean oil- or fish oil-rich diet or standard rat chow were sensitized twice with ovalbumin–alumen and challenged twice with ovalbumin aerosol. The BAL and lungs were examined 24 hours later. Results: Both diets, rich in n-6 or n-3 FAs, impaired the allergic lung inflammation and reduced leukocyte migration, eosinophil and neutrophil percentages, and IL-4/IL-5/bradykinin levels in BAL and/or lungs, as well as increased the nitric oxide levels in BAL. The soybean oil-rich diet additionally increased the levels of lipoxin A4 and corticosterone in the lungs. Conclusion: Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n-3 FA-rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airway inflammation. Keywords: asthma, nitric oxide, n-6 fatty acids, n-3 fatty acids, cytokines, lipoxin A4, bradykininNavarro-Xavier RABarros KVAndrade ISPalomino ZCasarini DEFlor Silveira VLDove Medical Pressarticleallergic airway inflammationn-6 fatty acidsn-3 fatty acidscytokineslipoxin A4bradykinin.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 79-89 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
allergic airway inflammation n-6 fatty acids n-3 fatty acids cytokines lipoxin A4 bradykinin. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
allergic airway inflammation n-6 fatty acids n-3 fatty acids cytokines lipoxin A4 bradykinin. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Navarro-Xavier RA Barros KV Andrade IS Palomino Z Casarini DE Flor Silveira VL Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| description |
Roberta Araujo Navarro-Xavier,1 Karina Vieira de Barros,1 Iracema Senna de Andrade,1 Zaira Palomino,2 Dulce Elena Casarini,2 Vera Lucia Flor Silveira3 1Departamento de Fisiologia, 2Departamento de Medicina, 3Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Diadema, São Paulo, Brazil Background: The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin [IL]-4, IL-5) and Th1 (interferon [IFN]-γ, tumor necrosis factor-α) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs. Methods: Male Wistar rats fed with soybean oil- or fish oil-rich diet or standard rat chow were sensitized twice with ovalbumin–alumen and challenged twice with ovalbumin aerosol. The BAL and lungs were examined 24 hours later. Results: Both diets, rich in n-6 or n-3 FAs, impaired the allergic lung inflammation and reduced leukocyte migration, eosinophil and neutrophil percentages, and IL-4/IL-5/bradykinin levels in BAL and/or lungs, as well as increased the nitric oxide levels in BAL. The soybean oil-rich diet additionally increased the levels of lipoxin A4 and corticosterone in the lungs. Conclusion: Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n-3 FA-rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airway inflammation. Keywords: asthma, nitric oxide, n-6 fatty acids, n-3 fatty acids, cytokines, lipoxin A4, bradykinin |
| format |
article |
| author |
Navarro-Xavier RA Barros KV Andrade IS Palomino Z Casarini DE Flor Silveira VL |
| author_facet |
Navarro-Xavier RA Barros KV Andrade IS Palomino Z Casarini DE Flor Silveira VL |
| author_sort |
Navarro-Xavier RA |
| title |
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| title_short |
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| title_full |
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| title_fullStr |
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| title_full_unstemmed |
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| title_sort |
protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/0827e6c58d494f19808a31bac4296d10 |
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