Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency

Sabine Kroiss, Manuela AlbisettiDivision of Hematology, University Children&rsquo;s Hospital, Zurich, SwitzerlandAbstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation. Severe congenital protein C deficiency leads to a hypercoagulab...

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Autores principales:	Sabine Kroiss, Manuela Albisetti
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/08281d4ded334a03a102e25ce501da85
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spelling	oai:doaj.org-article:08281d4ded334a03a102e25ce501da852021-12-02T01:15:07ZUse of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency1177-54751177-5491https://doaj.org/article/08281d4ded334a03a102e25ce501da852010-03-01T00:00:00Zhttp://www.dovepress.com/use-of-human-protein-c-concentrates-in-the-treatment-of-patients-with--a4043https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Sabine Kroiss, Manuela AlbisettiDivision of Hematology, University Children&rsquo;s Hospital, Zurich, SwitzerlandAbstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation. Severe congenital protein C deficiency leads to a hypercoagulability state that usually presents at birth with purpura fulminans and/or severe venous and arterial thrombosis. Recurrent thrombotic events are commonly seen. From the 1990&rsquo;s, several virus-inactivated human protein C concentrates have been developed. These concentrates currently constitute the therapy of choice for the treatment and prevention of clinical manifestations of severe congenital protein C deficiency. This review summarizes the available information on the use of human protein C concentrates in patients with severe congenital protein C deficiency.Keywords: Congenital protein C deficiency, protein C concentrate, purpura fulminans Sabine KroissManuela AlbisettiDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 51-60 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sabine Kroiss Manuela Albisetti Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
description	Sabine Kroiss, Manuela AlbisettiDivision of Hematology, University Children&rsquo;s Hospital, Zurich, SwitzerlandAbstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation. Severe congenital protein C deficiency leads to a hypercoagulability state that usually presents at birth with purpura fulminans and/or severe venous and arterial thrombosis. Recurrent thrombotic events are commonly seen. From the 1990&rsquo;s, several virus-inactivated human protein C concentrates have been developed. These concentrates currently constitute the therapy of choice for the treatment and prevention of clinical manifestations of severe congenital protein C deficiency. This review summarizes the available information on the use of human protein C concentrates in patients with severe congenital protein C deficiency.Keywords: Congenital protein C deficiency, protein C concentrate, purpura fulminans
format	article
author	Sabine Kroiss Manuela Albisetti
author_facet	Sabine Kroiss Manuela Albisetti
author_sort	Sabine Kroiss
title	Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
title_short	Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
title_full	Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
title_fullStr	Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
title_full_unstemmed	Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
title_sort	use of human protein c concentrates in the treatment of patients with severe congenital protein c deficiency
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/08281d4ded334a03a102e25ce501da85
work_keys_str_mv	AT sabinekroiss useofhumanproteincconcentratesinthetreatmentofpatientswithseverecongenitalproteincdeficiency AT manuelaalbisetti useofhumanproteincconcentratesinthetreatmentofpatientswithseverecongenitalproteincdeficiency
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Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency

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