Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner

Ming-Shan Wang,1 Liang Chen,2 Ya-Qiong Xiong,2 Jing Xu,2 Ji-Peng Wang,2 Zi-Li Meng2 1Department of Oncology, Huaiyin Hospital of Huai’an City, Huai’an, China; 2Department of Respiration, Huai’an First People’s Hospital, Nanjing Medical University, Huai&rs...

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Autores principales:	Wang MS, Chen L, Xiong YQ, Xu J, Wang JP, Meng ZL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	actein magnetic nanoparticles ofFe3O4 NSCLC apoptosis p53 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/08285e63fb75402a85e5cf6fd92d265e
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spelling	oai:doaj.org-article:08285e63fb75402a85e5cf6fd92d265e2021-12-02T02:51:42ZIron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner1178-2013https://doaj.org/article/08285e63fb75402a85e5cf6fd92d265e2017-10-01T00:00:00Zhttps://www.dovepress.com/iron-oxide-magnetic-nanoparticles-combined-with-actein-suppress-non-sm-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming-Shan Wang,1 Liang Chen,2 Ya-Qiong Xiong,2 Jing Xu,2 Ji-Peng Wang,2 Zi-Li Meng2 1Department of Oncology, Huaiyin Hospital of Huai’an City, Huai’an, China; 2Department of Respiration, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, China Abstract: Actein (AT) is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida that has been investigated for its antitumor effects. AT treatment leads to apoptosis in various cell types, including breast cancer cells, by regulating different signaling pathways. Iron oxide (Fe3O4) magnetic nanoparticles (MNPs) are nanomaterials with biocompatible activity and low toxicity. In the present study, the possible benefits of AT in combination with MNPs on non-small-cell lung cancer (NSCLC) were explored in in vitro and in vivo studies. AT-MNP treatment contributed to apoptosis in NSCLC cells, as evidenced by activation of the caspase 3-signaling pathway, which was accompanied by downregulation of the antiapoptotic proteins Bcl2 and BclXL, and upregulation of the proapoptotic signals Bax and Bad. The death receptors of TRAIL were also elevated following AT-MNP treatment in a p53-dependent manner. Furthermore, a mouse xenograft model in vivo revealed that AT-MNP treatment exhibited no toxicity and suppressed NSCLC growth compared to either AT or MNP monotherapies. In conclusion, this study suggests a novel therapy to induce apoptosis in suppressing NSCLC growth in a p53-dependent manner by combining AT with Fe3O4 MNPs. Keywords: actein, Fe3O4 magnetic nanoparticles, NSCLC, apoptosis, p53Wang MSChen LXiong YQXu JWang JPMeng ZLDove Medical Pressarticleacteinmagnetic nanoparticles ofFe3O4NSCLCapoptosisp53Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7627-7651 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	actein magnetic nanoparticles ofFe3O4 NSCLC apoptosis p53 Medicine (General) R5-920
spellingShingle	actein magnetic nanoparticles ofFe3O4 NSCLC apoptosis p53 Medicine (General) R5-920 Wang MS Chen L Xiong YQ Xu J Wang JP Meng ZL Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
description	Ming-Shan Wang,1 Liang Chen,2 Ya-Qiong Xiong,2 Jing Xu,2 Ji-Peng Wang,2 Zi-Li Meng2 1Department of Oncology, Huaiyin Hospital of Huai’an City, Huai’an, China; 2Department of Respiration, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, China Abstract: Actein (AT) is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida that has been investigated for its antitumor effects. AT treatment leads to apoptosis in various cell types, including breast cancer cells, by regulating different signaling pathways. Iron oxide (Fe3O4) magnetic nanoparticles (MNPs) are nanomaterials with biocompatible activity and low toxicity. In the present study, the possible benefits of AT in combination with MNPs on non-small-cell lung cancer (NSCLC) were explored in in vitro and in vivo studies. AT-MNP treatment contributed to apoptosis in NSCLC cells, as evidenced by activation of the caspase 3-signaling pathway, which was accompanied by downregulation of the antiapoptotic proteins Bcl2 and BclXL, and upregulation of the proapoptotic signals Bax and Bad. The death receptors of TRAIL were also elevated following AT-MNP treatment in a p53-dependent manner. Furthermore, a mouse xenograft model in vivo revealed that AT-MNP treatment exhibited no toxicity and suppressed NSCLC growth compared to either AT or MNP monotherapies. In conclusion, this study suggests a novel therapy to induce apoptosis in suppressing NSCLC growth in a p53-dependent manner by combining AT with Fe3O4 MNPs. Keywords: actein, Fe3O4 magnetic nanoparticles, NSCLC, apoptosis, p53
format	article
author	Wang MS Chen L Xiong YQ Xu J Wang JP Meng ZL
author_facet	Wang MS Chen L Xiong YQ Xu J Wang JP Meng ZL
author_sort	Wang MS
title	Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
title_short	Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
title_full	Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
title_fullStr	Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
title_full_unstemmed	Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
title_sort	iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/08285e63fb75402a85e5cf6fd92d265e
work_keys_str_mv	AT wangms ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner AT chenl ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner AT xiongyq ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner AT xuj ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner AT wangjp ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner AT mengzl ironoxidemagneticnanoparticlescombinedwithacteinsuppressnonsmallcelllungcancergrowthinap53dependentmanner
_version_	1718402082832121856

Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner

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