Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.

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Autores principales:	Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
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spelling	oai:doaj.org-article:082aa49bf9c74fc6ad7c119e84550fec2021-12-02T15:34:54ZPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network10.1038/ncomms107532041-1723https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10753https://doaj.org/toc/2041-1723Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.Elena SignaroldiPasquale LaiseSilvia CristofanonArianna BrancaccioElisa ReisoliSina AtashpazMaria Rosa TerreniClaudio DoglioniGiancarlo PruneriPaolo MalatestaGiuseppe TestaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
description	Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.
format	article
author	Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa
author_facet	Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa
author_sort	Elena Signaroldi
title	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_short	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_full	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_fullStr	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_full_unstemmed	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_sort	polycomb dysregulation in gliomagenesis targets a zfp423-dependent differentiation network
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
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Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

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