Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity

Abstract Kikuchi-Fujimoto disease (KFD) is usually self-limiting, but prolonged systemic symptoms often result in frequent hospital visits, long admission durations, or missed workdays. We investigated the role of fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hye Seong, Yong Hyu Jeong, Woon Ji Lee, Jun Hyoung Kim, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Jun Yong Choi, Yoon Soo Park, Joon Sup Yeom, Young Goo Song, Arthur Cho, Nam Su Ku
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/082c1765245a4cfe85805c6987c9b06c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:082c1765245a4cfe85805c6987c9b06c
record_format	dspace
spelling	oai:doaj.org-article:082c1765245a4cfe85805c6987c9b06c2021-12-02T15:00:40ZSplenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity10.1038/s41598-021-90350-z2045-2322https://doaj.org/article/082c1765245a4cfe85805c6987c9b06c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90350-zhttps://doaj.org/toc/2045-2322Abstract Kikuchi-Fujimoto disease (KFD) is usually self-limiting, but prolonged systemic symptoms often result in frequent hospital visits, long admission durations, or missed workdays. We investigated the role of fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing KFD severity. We reviewed the records of 31 adult patients with pathologically confirmed KFD who underwent 18F-FDG PET/CT between November 2007 and April 2018 at a tertiary-care referral hospital. Disease severity was assessed using criteria based on clinical manifestations of advanced KFD. Systemic activated lymph nodes and severity of splenic activation were determined using semi-quantitative and volumetric PET/CT parameters. The median of the mean splenic standardized uptake value (SUVmean) was higher in patients with severe KFD than those with mild KFD (2.38 ± 1.18 vs. 1.79 ± 0.99, p = 0.058). Patients with severe KFD had more systemically activated volume and glycolytic activity than those with mild KFD (total lesion glycolysis: 473.5 ± 504.4 vs. 201.6 ± 363.5, p = 0.024). Multivariate logistic regression showed that myalgia (odds ratio [OR] 0.035; 95% confidence interval [CI] 0.001–0.792; p = 0.035), total lymph node SUVmax (cutoff 9.27; OR 24.734; 95% CI 1.323–462.407; p = 0.032), and spleen SUVmean (cutoff 1.79; OR 37.770; 95% CI 1.769–806.583; p = 0.020) were significantly associated with severe KFD. 18F-FDG PET/CT could be useful in assessing KFD severity.Hye SeongYong Hyu JeongWoon Ji LeeJun Hyoung KimJung Ho KimJin Young AhnSu Jin JeongJun Yong ChoiYoon Soo ParkJoon Sup YeomYoung Goo SongArthur ChoNam Su KuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Seong Yong Hyu Jeong Woon Ji Lee Jun Hyoung Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Jun Yong Choi Yoon Soo Park Joon Sup Yeom Young Goo Song Arthur Cho Nam Su Ku Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
description	Abstract Kikuchi-Fujimoto disease (KFD) is usually self-limiting, but prolonged systemic symptoms often result in frequent hospital visits, long admission durations, or missed workdays. We investigated the role of fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing KFD severity. We reviewed the records of 31 adult patients with pathologically confirmed KFD who underwent 18F-FDG PET/CT between November 2007 and April 2018 at a tertiary-care referral hospital. Disease severity was assessed using criteria based on clinical manifestations of advanced KFD. Systemic activated lymph nodes and severity of splenic activation were determined using semi-quantitative and volumetric PET/CT parameters. The median of the mean splenic standardized uptake value (SUVmean) was higher in patients with severe KFD than those with mild KFD (2.38 ± 1.18 vs. 1.79 ± 0.99, p = 0.058). Patients with severe KFD had more systemically activated volume and glycolytic activity than those with mild KFD (total lesion glycolysis: 473.5 ± 504.4 vs. 201.6 ± 363.5, p = 0.024). Multivariate logistic regression showed that myalgia (odds ratio [OR] 0.035; 95% confidence interval [CI] 0.001–0.792; p = 0.035), total lymph node SUVmax (cutoff 9.27; OR 24.734; 95% CI 1.323–462.407; p = 0.032), and spleen SUVmean (cutoff 1.79; OR 37.770; 95% CI 1.769–806.583; p = 0.020) were significantly associated with severe KFD. 18F-FDG PET/CT could be useful in assessing KFD severity.
format	article
author	Hye Seong Yong Hyu Jeong Woon Ji Lee Jun Hyoung Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Jun Yong Choi Yoon Soo Park Joon Sup Yeom Young Goo Song Arthur Cho Nam Su Ku
author_facet	Hye Seong Yong Hyu Jeong Woon Ji Lee Jun Hyoung Kim Jung Ho Kim Jin Young Ahn Su Jin Jeong Jun Yong Choi Yoon Soo Park Joon Sup Yeom Young Goo Song Arthur Cho Nam Su Ku
author_sort	Hye Seong
title	Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
title_short	Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
title_full	Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
title_fullStr	Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
title_full_unstemmed	Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity
title_sort	splenic uptake on fdg pet/ct correlates with kikuchi-fujimoto disease severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/082c1765245a4cfe85805c6987c9b06c
work_keys_str_mv	AT hyeseong splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT yonghyujeong splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT woonjilee splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT junhyoungkim splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT junghokim splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT jinyoungahn splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT sujinjeong splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT junyongchoi splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT yoonsoopark splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT joonsupyeom splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT younggoosong splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT arthurcho splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity AT namsuku splenicuptakeonfdgpetctcorrelateswithkikuchifujimotodiseaseseverity
_version_	1718389119519817728

Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity

Ejemplares similares