The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.

<h4>Background</h4>Primary adenocarcinoma of the urinary bladder is rare. The molecular and cellular events leading to its pathogenesis are not well delineated. The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primar...

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Autores principales:	Riley E Alexander, Sean R Williamson, Justin Richey, Antonio Lopez-Beltran, Rodolfo Montironi, Darrell D Davidson, Muhammad T Idrees, Carol L Jones, Shaobo Zhang, Lisha Wang, Qiu Rao, Jose A Pedrosa, Hristos Z Kaimakliotis, M Francesca Monn, Michael O Koch, Liang Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/082d655b33ec43c19daeb3ec9347d0f4
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spelling	oai:doaj.org-article:082d655b33ec43c19daeb3ec9347d0f42021-11-18T08:22:08ZThe expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.1932-620310.1371/journal.pone.0095724https://doaj.org/article/082d655b33ec43c19daeb3ec9347d0f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24752337/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Primary adenocarcinoma of the urinary bladder is rare. The molecular and cellular events leading to its pathogenesis are not well delineated. The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primary bladder adenocarcinomas.<h4>Materials and methods</h4>Thirty six cases of urinary bladder adenocarcinoma were chosen from participating institutions. The diagnosis and available clinical history were reviewed in each case. Immunostains for p53, p16 and HPV and high-risk and low-risk HPV-ISH were performed on all tumors.<h4>Results</h4>Patients had an average age of 61 years with a male predominance (1.5 ∶ 1 male ∶ female ratio). The average tumor size in cystectomy specimens was 4.3 cm. Of the cases managed by transurethral resection, 40% were pT2 at the time of diagnosis. In cystectomy specimens, 77% were either pT3 or pT4. Strong nuclear p16 expression was seen in 67% of all cases and p53 expression was present in 58% of the cases. Expression of both markers was seen in 33% of cases. Expression of p16 or p53 alone was present in 12 (33%) and 9 (25%) cases, respectively. Neither marker was expressed in only 3 (8%) of the tumors. No significant correlation between clinical variables and any of the markers we studied was identified. No HPV infection was detected in any case.<h4>Conclusions</h4>Expression of p53 and/or p16 is very common in urinary bladder adenocarcinoma. These findings implicate a high likelihood that alterations in these cell cycle proteins contribute to the pathogenesis of these tumors. Despite frequent immunohistochemical labeling for p16, no evidence of HPV infection was found.Riley E AlexanderSean R WilliamsonJustin RicheyAntonio Lopez-BeltranRodolfo MontironiDarrell D DavidsonMuhammad T IdreesCarol L JonesShaobo ZhangLisha WangQiu RaoJose A PedrosaHristos Z KaimakliotisM Francesca MonnMichael O KochLiang ChengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95724 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Riley E Alexander Sean R Williamson Justin Richey Antonio Lopez-Beltran Rodolfo Montironi Darrell D Davidson Muhammad T Idrees Carol L Jones Shaobo Zhang Lisha Wang Qiu Rao Jose A Pedrosa Hristos Z Kaimakliotis M Francesca Monn Michael O Koch Liang Cheng The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
description	<h4>Background</h4>Primary adenocarcinoma of the urinary bladder is rare. The molecular and cellular events leading to its pathogenesis are not well delineated. The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primary bladder adenocarcinomas.<h4>Materials and methods</h4>Thirty six cases of urinary bladder adenocarcinoma were chosen from participating institutions. The diagnosis and available clinical history were reviewed in each case. Immunostains for p53, p16 and HPV and high-risk and low-risk HPV-ISH were performed on all tumors.<h4>Results</h4>Patients had an average age of 61 years with a male predominance (1.5 ∶ 1 male ∶ female ratio). The average tumor size in cystectomy specimens was 4.3 cm. Of the cases managed by transurethral resection, 40% were pT2 at the time of diagnosis. In cystectomy specimens, 77% were either pT3 or pT4. Strong nuclear p16 expression was seen in 67% of all cases and p53 expression was present in 58% of the cases. Expression of both markers was seen in 33% of cases. Expression of p16 or p53 alone was present in 12 (33%) and 9 (25%) cases, respectively. Neither marker was expressed in only 3 (8%) of the tumors. No significant correlation between clinical variables and any of the markers we studied was identified. No HPV infection was detected in any case.<h4>Conclusions</h4>Expression of p53 and/or p16 is very common in urinary bladder adenocarcinoma. These findings implicate a high likelihood that alterations in these cell cycle proteins contribute to the pathogenesis of these tumors. Despite frequent immunohistochemical labeling for p16, no evidence of HPV infection was found.
format	article
author	Riley E Alexander Sean R Williamson Justin Richey Antonio Lopez-Beltran Rodolfo Montironi Darrell D Davidson Muhammad T Idrees Carol L Jones Shaobo Zhang Lisha Wang Qiu Rao Jose A Pedrosa Hristos Z Kaimakliotis M Francesca Monn Michael O Koch Liang Cheng
author_facet	Riley E Alexander Sean R Williamson Justin Richey Antonio Lopez-Beltran Rodolfo Montironi Darrell D Davidson Muhammad T Idrees Carol L Jones Shaobo Zhang Lisha Wang Qiu Rao Jose A Pedrosa Hristos Z Kaimakliotis M Francesca Monn Michael O Koch Liang Cheng
author_sort	Riley E Alexander
title	The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
title_short	The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
title_full	The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
title_fullStr	The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
title_full_unstemmed	The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.
title_sort	expression patterns of p53 and p16 and an analysis of a possible role of hpv in primary adenocarcinoma of the urinary bladder.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/082d655b33ec43c19daeb3ec9347d0f4
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The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder.

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