Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids

Aging is one of the hottest topics in biomedicine. Previous research suggested that ω-3 fatty acids have preventive effects on aging. However, most of previous studies on the anti-aging effects of ω-3 fatty acids are focused on clinical observations, and the anti-aging mechanisms of ω-3 fatty acids...

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Autores principales:	Shu-Hui Xie, Hui Li, Jing-Jing Jiang, Yuan Quan, Hong-Yu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ω-3 fatty acids aging methylation Mendelian randomization gut microbiome Genetics QH426-470
Acceso en línea:	https://doaj.org/article/082e8e585b5d4787ae439a09723a814f
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spelling	oai:doaj.org-article:082e8e585b5d4787ae439a09723a814f2021-11-25T17:40:52ZMulti-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids10.3390/genes121116912073-4425https://doaj.org/article/082e8e585b5d4787ae439a09723a814f2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1691https://doaj.org/toc/2073-4425Aging is one of the hottest topics in biomedicine. Previous research suggested that ω-3 fatty acids have preventive effects on aging. However, most of previous studies on the anti-aging effects of ω-3 fatty acids are focused on clinical observations, and the anti-aging mechanisms of ω-3 fatty acids have not been fully elucidated. This stimulated our interest to use multi-omics data related to ω-3 fatty acids in order to interpret the anti-aging mechanisms of ω-3 fatty acids. First, we found that ω-3 fatty acids can affect methylation levels and expression levels of genes associated with age-related diseases or pathways in humans. Then, a Mendelian randomization analysis was conducted to determine whether there is a causal relationship between the effect of ω-3 fatty acids on blood lipid levels and variation in the gut microbiome. Our results indicate that the impact of ω-3 fatty acids on aging is partially mediated by the gut microbiome (including <i>Actinobacteria, Bifidobacteria</i> and <i>Streptococcus</i>). In conclusion, this study provides deeper insights into the anti-aging mechanisms of ω-3 fatty acids and supports the dietary supplementation of ω-3 fatty acids in aging prevention.Shu-Hui XieHui LiJing-Jing JiangYuan QuanHong-Yu ZhangMDPI AGarticleω-3 fatty acidsagingmethylationMendelian randomizationgut microbiomeGeneticsQH426-470ENGenes, Vol 12, Iss 1691, p 1691 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ω-3 fatty acids aging methylation Mendelian randomization gut microbiome Genetics QH426-470
spellingShingle	ω-3 fatty acids aging methylation Mendelian randomization gut microbiome Genetics QH426-470 Shu-Hui Xie Hui Li Jing-Jing Jiang Yuan Quan Hong-Yu Zhang Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
description	Aging is one of the hottest topics in biomedicine. Previous research suggested that ω-3 fatty acids have preventive effects on aging. However, most of previous studies on the anti-aging effects of ω-3 fatty acids are focused on clinical observations, and the anti-aging mechanisms of ω-3 fatty acids have not been fully elucidated. This stimulated our interest to use multi-omics data related to ω-3 fatty acids in order to interpret the anti-aging mechanisms of ω-3 fatty acids. First, we found that ω-3 fatty acids can affect methylation levels and expression levels of genes associated with age-related diseases or pathways in humans. Then, a Mendelian randomization analysis was conducted to determine whether there is a causal relationship between the effect of ω-3 fatty acids on blood lipid levels and variation in the gut microbiome. Our results indicate that the impact of ω-3 fatty acids on aging is partially mediated by the gut microbiome (including <i>Actinobacteria, Bifidobacteria</i> and <i>Streptococcus</i>). In conclusion, this study provides deeper insights into the anti-aging mechanisms of ω-3 fatty acids and supports the dietary supplementation of ω-3 fatty acids in aging prevention.
format	article
author	Shu-Hui Xie Hui Li Jing-Jing Jiang Yuan Quan Hong-Yu Zhang
author_facet	Shu-Hui Xie Hui Li Jing-Jing Jiang Yuan Quan Hong-Yu Zhang
author_sort	Shu-Hui Xie
title	Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
title_short	Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
title_full	Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
title_fullStr	Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
title_full_unstemmed	Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids
title_sort	multi-omics interpretation of anti-aging mechanisms for ω-3 fatty acids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/082e8e585b5d4787ae439a09723a814f
work_keys_str_mv	AT shuhuixie multiomicsinterpretationofantiagingmechanismsforō3fattyacids AT huili multiomicsinterpretationofantiagingmechanismsforō3fattyacids AT jingjingjiang multiomicsinterpretationofantiagingmechanismsforō3fattyacids AT yuanquan multiomicsinterpretationofantiagingmechanismsforō3fattyacids AT hongyuzhang multiomicsinterpretationofantiagingmechanismsforō3fattyacids
_version_	1718412087463510016

Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids

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