Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of...

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Autores principales:	Zdenek Andrysik, Heather Bender, Matthew D. Galbraith, Joaquin M. Espinosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08311375eed848a4a71efdc960482a8f
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spelling	oai:doaj.org-article:08311375eed848a4a71efdc960482a8f2021-12-02T13:34:29ZMulti-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response10.1038/s41467-021-21687-22041-1723https://doaj.org/article/08311375eed848a4a71efdc960482a8f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21687-2https://doaj.org/toc/2041-1723The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer.Zdenek AndrysikHeather BenderMatthew D. GalbraithJoaquin M. EspinosaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
description	The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer.
format	article
author	Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa
author_facet	Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa
author_sort	Zdenek Andrysik
title	Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
title_short	Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
title_full	Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
title_fullStr	Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
title_full_unstemmed	Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
title_sort	multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08311375eed848a4a71efdc960482a8f
work_keys_str_mv	AT zdenekandrysik multiomicsanalysisrevealscontextualtumorsuppressiveandoncogenicgenemoduleswithintheacutehypoxicresponse AT heatherbender multiomicsanalysisrevealscontextualtumorsuppressiveandoncogenicgenemoduleswithintheacutehypoxicresponse AT matthewdgalbraith multiomicsanalysisrevealscontextualtumorsuppressiveandoncogenicgenemoduleswithintheacutehypoxicresponse AT joaquinmespinosa multiomicsanalysisrevealscontextualtumorsuppressiveandoncogenicgenemoduleswithintheacutehypoxicresponse
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Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

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