Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes

Abstract Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus...

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Autores principales:	Jonathan A. Shulgach, Dylan W. Beam, Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Michael Sciullo, John Ogren, Liane Wong, Bryan L. McLaughlin, Bill J. Yates, Charles C. Horn, Lee E. Fisher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0831dae6ed9b4619a2ae97b91b5a680b
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spelling	oai:doaj.org-article:0831dae6ed9b4619a2ae97b91b5a680b2021-12-02T18:02:49ZSelective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes10.1038/s41598-021-91900-12045-2322https://doaj.org/article/0831dae6ed9b4619a2ae97b91b5a680b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91900-1https://doaj.org/toc/2045-2322Abstract Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus nerve also innervates many other organs throughout the body, and off-target effects of VNS could cause major side effects such as changes in blood pressure. In this study, we aimed to achieve selective stimulation of populations of vagal afferents using a multi-contact cuff electrode wrapped around the abdominal trunks of the vagus nerve. Four-contact nerve cuff electrodes were implanted around the dorsal (N = 3) or ventral (N = 3) abdominal vagus nerve in six ferrets, and the response to stimulation was measured via a 32-channel microelectrode array (MEA) inserted into the left or right nodose ganglion. Selectivity was characterized by the ability to evoke responses in MEA channels through one bipolar pair of cuff contacts but not through the other bipolar pair. We demonstrated that it was possible to selectively activate subpopulations of vagal neurons using abdominal VNS. Additionally, we quantified the conduction velocity of evoked responses to determine what types of nerve fibers (i.e., Aδ vs. C) responded to stimulation. We also quantified the spatial organization of evoked responses in the nodose MEA to determine if there is somatotopic organization of the neurons in that ganglion. Finally, we demonstrated in a separate set of three ferrets that stimulation of the abdominal vagus via a four-contact cuff could selectively alter gastric myoelectric activity, suggesting that abdominal VNS can potentially be used to control GI function.Jonathan A. ShulgachDylan W. BeamAmeya C. NanivadekarDerek M. MillerStephanie FultonMichael SciulloJohn OgrenLiane WongBryan L. McLaughlinBill J. YatesCharles C. HornLee E. FisherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonathan A. Shulgach Dylan W. Beam Ameya C. Nanivadekar Derek M. Miller Stephanie Fulton Michael Sciullo John Ogren Liane Wong Bryan L. McLaughlin Bill J. Yates Charles C. Horn Lee E. Fisher Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
description	Abstract Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus nerve also innervates many other organs throughout the body, and off-target effects of VNS could cause major side effects such as changes in blood pressure. In this study, we aimed to achieve selective stimulation of populations of vagal afferents using a multi-contact cuff electrode wrapped around the abdominal trunks of the vagus nerve. Four-contact nerve cuff electrodes were implanted around the dorsal (N = 3) or ventral (N = 3) abdominal vagus nerve in six ferrets, and the response to stimulation was measured via a 32-channel microelectrode array (MEA) inserted into the left or right nodose ganglion. Selectivity was characterized by the ability to evoke responses in MEA channels through one bipolar pair of cuff contacts but not through the other bipolar pair. We demonstrated that it was possible to selectively activate subpopulations of vagal neurons using abdominal VNS. Additionally, we quantified the conduction velocity of evoked responses to determine what types of nerve fibers (i.e., Aδ vs. C) responded to stimulation. We also quantified the spatial organization of evoked responses in the nodose MEA to determine if there is somatotopic organization of the neurons in that ganglion. Finally, we demonstrated in a separate set of three ferrets that stimulation of the abdominal vagus via a four-contact cuff could selectively alter gastric myoelectric activity, suggesting that abdominal VNS can potentially be used to control GI function.
format	article
author	Jonathan A. Shulgach Dylan W. Beam Ameya C. Nanivadekar Derek M. Miller Stephanie Fulton Michael Sciullo John Ogren Liane Wong Bryan L. McLaughlin Bill J. Yates Charles C. Horn Lee E. Fisher
author_facet	Jonathan A. Shulgach Dylan W. Beam Ameya C. Nanivadekar Derek M. Miller Stephanie Fulton Michael Sciullo John Ogren Liane Wong Bryan L. McLaughlin Bill J. Yates Charles C. Horn Lee E. Fisher
author_sort	Jonathan A. Shulgach
title	Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
title_short	Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
title_full	Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
title_fullStr	Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
title_full_unstemmed	Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
title_sort	selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0831dae6ed9b4619a2ae97b91b5a680b
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Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes

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