Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study

The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finge...

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Autores principales:	Salma Charfeddine, Hassen Ibn Hadj Amor, Jihen Jdidi, Slim Torjmen, Salma Kraiem, Rania Hammami, Amine Bahloul, Nesrine Kallel, Nedia Moussa, Imen Touil, Aiman Ghrab, Jamel Elghoul, Zineb Meddeb, Yamina Thabet, Samir Kammoun, Kamel Bouslama, Sami Milouchi, Salem Abdessalem, Leila Abid
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 long COVID-19 syndrome endothelial function microcirculation endothelium Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/08326ba4197546f5bcb03c52e72badf1
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spelling	oai:doaj.org-article:08326ba4197546f5bcb03c52e72badf12021-12-01T19:43:35ZLong COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study2297-055X10.3389/fcvm.2021.745758https://doaj.org/article/08326ba4197546f5bcb03c52e72badf12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.745758/fullhttps://doaj.org/toc/2297-055XThe COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC95% [1.95–2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.Salma CharfeddineSalma CharfeddineHassen Ibn Hadj AmorJihen JdidiJihen JdidiSlim TorjmenSlim TorjmenSalma KraiemRania HammamiRania HammamiAmine BahloulAmine BahloulNesrine KallelNesrine KallelNedia MoussaNedia MoussaImen TouilAiman GhrabJamel ElghoulJamel ElghoulZineb MeddebYamina ThabetSamir KammounSamir KammounKamel BouslamaSami MilouchiSami MilouchiSalem AbdessalemLeila AbidLeila AbidFrontiers Media S.A.articleCOVID-19long COVID-19 syndromeendothelial functionmicrocirculationendotheliumDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 long COVID-19 syndrome endothelial function microcirculation endothelium Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	COVID-19 long COVID-19 syndrome endothelial function microcirculation endothelium Diseases of the circulatory (Cardiovascular) system RC666-701 Salma Charfeddine Salma Charfeddine Hassen Ibn Hadj Amor Jihen Jdidi Jihen Jdidi Slim Torjmen Slim Torjmen Salma Kraiem Rania Hammami Rania Hammami Amine Bahloul Amine Bahloul Nesrine Kallel Nesrine Kallel Nedia Moussa Nedia Moussa Imen Touil Aiman Ghrab Jamel Elghoul Jamel Elghoul Zineb Meddeb Yamina Thabet Samir Kammoun Samir Kammoun Kamel Bouslama Sami Milouchi Sami Milouchi Salem Abdessalem Leila Abid Leila Abid Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
description	The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC95% [1.95–2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.
format	article
author	Salma Charfeddine Salma Charfeddine Hassen Ibn Hadj Amor Jihen Jdidi Jihen Jdidi Slim Torjmen Slim Torjmen Salma Kraiem Rania Hammami Rania Hammami Amine Bahloul Amine Bahloul Nesrine Kallel Nesrine Kallel Nedia Moussa Nedia Moussa Imen Touil Aiman Ghrab Jamel Elghoul Jamel Elghoul Zineb Meddeb Yamina Thabet Samir Kammoun Samir Kammoun Kamel Bouslama Sami Milouchi Sami Milouchi Salem Abdessalem Leila Abid Leila Abid
author_facet	Salma Charfeddine Salma Charfeddine Hassen Ibn Hadj Amor Jihen Jdidi Jihen Jdidi Slim Torjmen Slim Torjmen Salma Kraiem Rania Hammami Rania Hammami Amine Bahloul Amine Bahloul Nesrine Kallel Nesrine Kallel Nedia Moussa Nedia Moussa Imen Touil Aiman Ghrab Jamel Elghoul Jamel Elghoul Zineb Meddeb Yamina Thabet Samir Kammoun Samir Kammoun Kamel Bouslama Sami Milouchi Sami Milouchi Salem Abdessalem Leila Abid Leila Abid
author_sort	Salma Charfeddine
title	Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
title_short	Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
title_full	Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
title_fullStr	Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
title_full_unstemmed	Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
title_sort	long covid 19 syndrome: is it related to microcirculation and endothelial dysfunction? insights from tun-endcov study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/08326ba4197546f5bcb03c52e72badf1
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Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study

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