Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease

Abstract Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI...

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Autores principales:	Hsin-Hsi Tsai, Li-Kai Tsai, Yen-Ling Lo, Chin-Hsien Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08340ee754b14fd19a0cc03c0b7cbbcf
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spelling	oai:doaj.org-article:08340ee754b14fd19a0cc03c0b7cbbcf2021-12-02T13:26:28ZAmyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease10.1038/s41598-021-86617-02045-2322https://doaj.org/article/08340ee754b14fd19a0cc03c0b7cbbcf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86617-0https://doaj.org/toc/2045-2322Abstract Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI and plasma biomarker assays, including tau, Aβ42, Aβ40, and α-synuclein. PD with dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 and advanced motor stage was defined as Hoehn-Yahr stage ≥ 3 during “on” status. The association between MBs and disease severity was examined using multivariate logistic regression models. More lobar MBs were observed in PD patients than controls (20.7% vs. 3.3%, p = 0.031). PDD patients had more lobar MBs (33.3% vs. 15.6%, p = 0.034), more white matter hyperintensity (p = 0.021) and reduced hippocampal volume (p = 0.001) than PD with normal cognition. The presence of lobar MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) and severe white matter hyperintensity (3.29 [1.21–8.96], p = 0.020) was independently associated with PDD after adjusting for vascular risk factors and other confounders. Furthermore, plasma Aβ40 levels were associated the MMSE score (p = 0.004) after adjusting for age and sex. Our findings demonstrated that lobar MBs, reduced hippocampal volume, and elevated plasma Aβ40 levels are associated with PDD.Hsin-Hsi TsaiLi-Kai TsaiYen-Ling LoChin-Hsien LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Hsi Tsai Li-Kai Tsai Yen-Ling Lo Chin-Hsien Lin Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
description	Abstract Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI and plasma biomarker assays, including tau, Aβ42, Aβ40, and α-synuclein. PD with dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 and advanced motor stage was defined as Hoehn-Yahr stage ≥ 3 during “on” status. The association between MBs and disease severity was examined using multivariate logistic regression models. More lobar MBs were observed in PD patients than controls (20.7% vs. 3.3%, p = 0.031). PDD patients had more lobar MBs (33.3% vs. 15.6%, p = 0.034), more white matter hyperintensity (p = 0.021) and reduced hippocampal volume (p = 0.001) than PD with normal cognition. The presence of lobar MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) and severe white matter hyperintensity (3.29 [1.21–8.96], p = 0.020) was independently associated with PDD after adjusting for vascular risk factors and other confounders. Furthermore, plasma Aβ40 levels were associated the MMSE score (p = 0.004) after adjusting for age and sex. Our findings demonstrated that lobar MBs, reduced hippocampal volume, and elevated plasma Aβ40 levels are associated with PDD.
format	article
author	Hsin-Hsi Tsai Li-Kai Tsai Yen-Ling Lo Chin-Hsien Lin
author_facet	Hsin-Hsi Tsai Li-Kai Tsai Yen-Ling Lo Chin-Hsien Lin
author_sort	Hsin-Hsi Tsai
title	Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
title_short	Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
title_full	Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
title_fullStr	Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
title_full_unstemmed	Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
title_sort	amyloid related cerebral microbleed and plasma aβ40 are associated with cognitive decline in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08340ee754b14fd19a0cc03c0b7cbbcf
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Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease

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