Enhancement of the Local CD8<sup>+</sup> T-Cellular Immune Response to <i>Mycobacterium tuberculosis</i> in BCG-Primed Mice after Intranasal Administration of Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens

Enhancement of the Local CD8<sup>+</sup> T-Cellular Immune Response to <i>Mycobacterium tuberculosis</i> in BCG-Primed Mice after Intranasal Administration of Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens

BCG is the only licensed vaccine against <i>Mycobacterium tuberculosis (M.tb)</i> infection. Due to its intramuscular administration route, BCG is unable to induce a local protective immune response in the respiratory system. Moreover, BCG has a diminished ability to induce long-lived me...

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Autores principales: Kirill Vasilyev, Anna-Polina Shurygina, Natalia Zabolotnykh, Mariia Sergeeva, Ekaterina Romanovskaya-Romanko, Anastasia Pulkina, Janna Buzitskaya, Marine Z. Dogonadze, Tatiana I. Vinogradova, Marina A. Stukova
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>M. tuberculosis</i> vaccine
TB10.4
HspX
influenza vector
mucosal immunization
innate immune response
Medicine
R
Acceso en línea:https://doaj.org/article/0834a9890ac0450ea8bb455b9f114e17
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