Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.

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Autores principales:	Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd4162
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spelling	oai:doaj.org-article:0839cad1dc084b31b2fb1c7ae7cd41622021-12-02T15:34:36ZCardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein10.1038/s41467-018-03241-92041-1723https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd41622018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03241-9https://doaj.org/toc/2041-1723Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.Tammy RyanVladimir V. BammMorgan G. StykelCarla L. CoackleyKayla M. HumphriesRhiannon Jamieson-WilliamsRajesh AmbasudhanDick D. MosserStuart A. LiptonGeorge HarauzScott D. RyanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tammy Ryan Vladimir V. Bamm Morgan G. Stykel Carla L. Coackley Kayla M. Humphries Rhiannon Jamieson-Williams Rajesh Ambasudhan Dick D. Mosser Stuart A. Lipton George Harauz Scott D. Ryan Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
description	Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
format	article
author	Tammy Ryan Vladimir V. Bamm Morgan G. Stykel Carla L. Coackley Kayla M. Humphries Rhiannon Jamieson-Williams Rajesh Ambasudhan Dick D. Mosser Stuart A. Lipton George Harauz Scott D. Ryan
author_facet	Tammy Ryan Vladimir V. Bamm Morgan G. Stykel Carla L. Coackley Kayla M. Humphries Rhiannon Jamieson-Williams Rajesh Ambasudhan Dick D. Mosser Stuart A. Lipton George Harauz Scott D. Ryan
author_sort	Tammy Ryan
title	Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
title_short	Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
title_full	Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
title_fullStr	Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
title_full_unstemmed	Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
title_sort	cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd4162
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Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

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