Interactions of platelets with circulating tumor cells contribute to cancer metastasis

Abstract Recent studies have suggested that platelets have a crucial role in enhancing the survival of circulating tumor cells in the bloodstream and aggravating cancer metastasis. The main function of platelets is to bind to the sites of the damaged vessels to stop bleeding. However, in cancer pati...

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Autores principales:	Sina Anvari, Ernest Osei, Nima Maftoon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/083ac39ee3084df9b573bfa03febf8f2
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spelling	oai:doaj.org-article:083ac39ee3084df9b573bfa03febf8f22021-12-02T16:06:41ZInteractions of platelets with circulating tumor cells contribute to cancer metastasis10.1038/s41598-021-94735-y2045-2322https://doaj.org/article/083ac39ee3084df9b573bfa03febf8f22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94735-yhttps://doaj.org/toc/2045-2322Abstract Recent studies have suggested that platelets have a crucial role in enhancing the survival of circulating tumor cells in the bloodstream and aggravating cancer metastasis. The main function of platelets is to bind to the sites of the damaged vessels to stop bleeding. However, in cancer patients, activated platelets adhere to circulating tumor cells and exacerbate metastatic spreading. Several hypotheses have been proposed about the platelet–cancer cell interactions, but the underlying mechanisms of these interactions are not completely understood yet. In this work, we quantitatively investigated the interactions between circulating tumor cells, red blood cells, platelets, plasma flow and microvessel walls via computational modelling at the cellular scale. Our highly detailed computational model allowed us to understand and quantitatively explain the role of platelets in deformation, adhesion and survival of tumor cells in their active arrest to the endothelium.Sina AnvariErnest OseiNima MaftoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sina Anvari Ernest Osei Nima Maftoon Interactions of platelets with circulating tumor cells contribute to cancer metastasis
description	Abstract Recent studies have suggested that platelets have a crucial role in enhancing the survival of circulating tumor cells in the bloodstream and aggravating cancer metastasis. The main function of platelets is to bind to the sites of the damaged vessels to stop bleeding. However, in cancer patients, activated platelets adhere to circulating tumor cells and exacerbate metastatic spreading. Several hypotheses have been proposed about the platelet–cancer cell interactions, but the underlying mechanisms of these interactions are not completely understood yet. In this work, we quantitatively investigated the interactions between circulating tumor cells, red blood cells, platelets, plasma flow and microvessel walls via computational modelling at the cellular scale. Our highly detailed computational model allowed us to understand and quantitatively explain the role of platelets in deformation, adhesion and survival of tumor cells in their active arrest to the endothelium.
format	article
author	Sina Anvari Ernest Osei Nima Maftoon
author_facet	Sina Anvari Ernest Osei Nima Maftoon
author_sort	Sina Anvari
title	Interactions of platelets with circulating tumor cells contribute to cancer metastasis
title_short	Interactions of platelets with circulating tumor cells contribute to cancer metastasis
title_full	Interactions of platelets with circulating tumor cells contribute to cancer metastasis
title_fullStr	Interactions of platelets with circulating tumor cells contribute to cancer metastasis
title_full_unstemmed	Interactions of platelets with circulating tumor cells contribute to cancer metastasis
title_sort	interactions of platelets with circulating tumor cells contribute to cancer metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/083ac39ee3084df9b573bfa03febf8f2
work_keys_str_mv	AT sinaanvari interactionsofplateletswithcirculatingtumorcellscontributetocancermetastasis AT ernestosei interactionsofplateletswithcirculatingtumorcellscontributetocancermetastasis AT nimamaftoon interactionsofplateletswithcirculatingtumorcellscontributetocancermetastasis
_version_	1718384883543310336

Interactions of platelets with circulating tumor cells contribute to cancer metastasis

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