Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

The transcription factor, IRF5, has been implicated in the regulation of inflammation, but how IRF5 protein is activated is still unclear. Here the authors use inhibitor library screening, biochemical analyses and in vivo/ex vivo data to show that a protein tyrosine kinase, Pyk2, may be key for the...

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Autores principales:	Grigory Ryzhakov, Hannah Almuttaqi, Alastair L. Corbin, Dorothée L. Berthold, Tariq Khoyratty, Hayley L. Eames, Samuel Bullers, Claire Pearson, Zhichao Ai, Kristina Zec, Sarah Bonham, Roman Fischer, Luke Jostins-Dean, Simon P. L. Travis, Benedikt M. Kessler, Irina A. Udalova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/083b7a2470054dbf911ff4a0bab0a0ba
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spelling	oai:doaj.org-article:083b7a2470054dbf911ff4a0bab0a0ba2021-11-21T12:34:43ZDefactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation10.1038/s41467-021-27038-52041-1723https://doaj.org/article/083b7a2470054dbf911ff4a0bab0a0ba2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27038-5https://doaj.org/toc/2041-1723The transcription factor, IRF5, has been implicated in the regulation of inflammation, but how IRF5 protein is activated is still unclear. Here the authors use inhibitor library screening, biochemical analyses and in vivo/ex vivo data to show that a protein tyrosine kinase, Pyk2, may be key for the activation of IRF5 in macrophages and inflammatory responses in the gut.Grigory RyzhakovHannah AlmuttaqiAlastair L. CorbinDorothée L. BertholdTariq KhoyrattyHayley L. EamesSamuel BullersClaire PearsonZhichao AiKristina ZecSarah BonhamRoman FischerLuke Jostins-DeanSimon P. L. TravisBenedikt M. KesslerIrina A. UdalovaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grigory Ryzhakov Hannah Almuttaqi Alastair L. Corbin Dorothée L. Berthold Tariq Khoyratty Hayley L. Eames Samuel Bullers Claire Pearson Zhichao Ai Kristina Zec Sarah Bonham Roman Fischer Luke Jostins-Dean Simon P. L. Travis Benedikt M. Kessler Irina A. Udalova Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
description	The transcription factor, IRF5, has been implicated in the regulation of inflammation, but how IRF5 protein is activated is still unclear. Here the authors use inhibitor library screening, biochemical analyses and in vivo/ex vivo data to show that a protein tyrosine kinase, Pyk2, may be key for the activation of IRF5 in macrophages and inflammatory responses in the gut.
format	article
author	Grigory Ryzhakov Hannah Almuttaqi Alastair L. Corbin Dorothée L. Berthold Tariq Khoyratty Hayley L. Eames Samuel Bullers Claire Pearson Zhichao Ai Kristina Zec Sarah Bonham Roman Fischer Luke Jostins-Dean Simon P. L. Travis Benedikt M. Kessler Irina A. Udalova
author_facet	Grigory Ryzhakov Hannah Almuttaqi Alastair L. Corbin Dorothée L. Berthold Tariq Khoyratty Hayley L. Eames Samuel Bullers Claire Pearson Zhichao Ai Kristina Zec Sarah Bonham Roman Fischer Luke Jostins-Dean Simon P. L. Travis Benedikt M. Kessler Irina A. Udalova
author_sort	Grigory Ryzhakov
title	Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
title_short	Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
title_full	Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
title_fullStr	Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
title_full_unstemmed	Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
title_sort	defactinib inhibits pyk2 phosphorylation of irf5 and reduces intestinal inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/083b7a2470054dbf911ff4a0bab0a0ba
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Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

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