The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver

BACKGROUND AND OBJECTIVE: A high-fat diet can disrupt the antioxidant system and damage the liver. One of the most important ways to control non-alcoholic fatty liver is to use natural compounds with antioxidant properties. Therefore, this study was performed to evaluate the effect of coconut oil on...

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Autores principales:	M Arsang, I Khodadadi, H Tyebinia, E Abbasi-Oshaghi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	coconut oil fatty liver rat. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/083d14f68f7249b28c3da7fc443f90d2
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spelling	oai:doaj.org-article:083d14f68f7249b28c3da7fc443f90d22021-11-09T10:15:54ZThe Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver1561-41072251-7170https://doaj.org/article/083d14f68f7249b28c3da7fc443f90d22020-03-01T00:00:00Zhttp://jbums.org/article-1-9035-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: A high-fat diet can disrupt the antioxidant system and damage the liver. One of the most important ways to control non-alcoholic fatty liver is to use natural compounds with antioxidant properties. Therefore, this study was performed to evaluate the effect of coconut oil on cholesterol, triglyceride and antioxidant status in high-fat diet- induced rat liver. METHODS: In this experimental study, 30 male rats were randomly divided into 6 groups of 5 including: 1) control group, 2 and 3) control+10% and 8% virgin coconut oil, 4) only receiving high fat diet, and 5 and 6) receiving high fat diet+10% and 8% virgin coconut oil. Coconut oil was prepared daily and mixed with animal food. At the end of the study, the rats were anesthetized and liver tissue was isolated and used for antioxidant tests. FINDINGS: In this study, the levels of triglyceride (159±11.5) in the high-fat diet group increased significantly compared to the control (64±4.2) (p<0.001). Treatment of high-fat diet group with coconut oil at doses of 8% (104.5±9.1) and 10% (97.5±8.2) was able to reduce triglyceride levels (p<0.05) significantly. Cholesterol (118±6.7) in the high-fat diet group increased significantly compared to the control (60±6.6) (p<0.001). Treatment of high-fat diet group with coconut oil at a dose of 10% (94±5.3) was able to reduce cholesterol (p<0.01) significantly. CONCLUSION: According to the results of this study, virgin coconut oil can be useful in the treatment of fatty liver by reducing lipids and increasing antioxidants.M ArsangI KhodadadiH TyebiniaE Abbasi-OshaghiBabol University of Medical Sciencesarticlecoconut oilfatty liverrat.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 245-252 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	coconut oil fatty liver rat. Medicine R Medicine (General) R5-920
spellingShingle	coconut oil fatty liver rat. Medicine R Medicine (General) R5-920 M Arsang I Khodadadi H Tyebinia E Abbasi-Oshaghi The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
description	BACKGROUND AND OBJECTIVE: A high-fat diet can disrupt the antioxidant system and damage the liver. One of the most important ways to control non-alcoholic fatty liver is to use natural compounds with antioxidant properties. Therefore, this study was performed to evaluate the effect of coconut oil on cholesterol, triglyceride and antioxidant status in high-fat diet- induced rat liver. METHODS: In this experimental study, 30 male rats were randomly divided into 6 groups of 5 including: 1) control group, 2 and 3) control+10% and 8% virgin coconut oil, 4) only receiving high fat diet, and 5 and 6) receiving high fat diet+10% and 8% virgin coconut oil. Coconut oil was prepared daily and mixed with animal food. At the end of the study, the rats were anesthetized and liver tissue was isolated and used for antioxidant tests. FINDINGS: In this study, the levels of triglyceride (159±11.5) in the high-fat diet group increased significantly compared to the control (64±4.2) (p<0.001). Treatment of high-fat diet group with coconut oil at doses of 8% (104.5±9.1) and 10% (97.5±8.2) was able to reduce triglyceride levels (p<0.05) significantly. Cholesterol (118±6.7) in the high-fat diet group increased significantly compared to the control (60±6.6) (p<0.001). Treatment of high-fat diet group with coconut oil at a dose of 10% (94±5.3) was able to reduce cholesterol (p<0.01) significantly. CONCLUSION: According to the results of this study, virgin coconut oil can be useful in the treatment of fatty liver by reducing lipids and increasing antioxidants.
format	article
author	M Arsang I Khodadadi H Tyebinia E Abbasi-Oshaghi
author_facet	M Arsang I Khodadadi H Tyebinia E Abbasi-Oshaghi
author_sort	M Arsang
title	The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
title_short	The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
title_full	The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
title_fullStr	The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
title_full_unstemmed	The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver
title_sort	protective effects of virgin coconut oil on high-fat diet induced rat liver
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/083d14f68f7249b28c3da7fc443f90d2
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The Protective Effects of Virgin Coconut Oil on High-Fat Diet Induced Rat Liver

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