Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies

Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies

Auxin-mediated recruitment of AUX/IAAs by the F-box protein TIR1 prompts rapid AUX/IAA ubiquitylation and degradation. By resolving auxin receptor topology, the authors show that intrinsically disordered regions near the degrons of two Aux/IAA proteins reinforce complex assembly and position Aux/IAA...

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Main Authors: Michael Niemeyer, Elena Moreno Castillo, Christian H. Ihling, Claudio Iacobucci, Verona Wilde, Antje Hellmuth, Wolfgang Hoehenwarter, Sophia L. Samodelov, Matias D. Zurbriggen, Panagiotis L. Kastritis, Andrea Sinz, Luz Irina A. Calderón Villalobos
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/083d3139070748c996146102b870ffe1
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https://doaj.org/article/083d3139070748c996146102b870ffe1

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