Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

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Autores principales:	Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
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spelling	oai:doaj.org-article:0841d30974ee49439a137cb5c41e499b2021-12-02T15:35:04ZSmall-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia10.1038/s41467-019-10523-32041-1723https://doaj.org/article/0841d30974ee49439a137cb5c41e499b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10523-3https://doaj.org/toc/2041-1723The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.Gerard MinuesaSteven K. AlbaneseWei XieYaniv KazanskyDaniel WorrollArthur ChowAlexandra SchurerSun-Mi ParkChristina Z. RotsidesJames TaggartAndrea RizziLevi N. NadenTimothy ChouSaroj GourkantiDaniel CappelMaria C. PassarelliLauren FairchildCarolina AduraJ. Fraser GlickmanJessica SchulmanChristopher FamulareMinal PatelJoseph K. EiblGregory M. RossShibani BhattacharyaDerek S. TanChristina S. LeslieThijs BeumingDinshaw J. PatelYehuda GoldgurJohn D. ChoderaMichael G. KharasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
description	The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
format	article
author	Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas
author_facet	Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas
author_sort	Gerard Minuesa
title	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
title_short	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
title_full	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
title_fullStr	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
title_full_unstemmed	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
title_sort	small-molecule targeting of musashi rna-binding activity in acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
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Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

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