Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells

Objective. The aim of the present investigation was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of genes encoding glucocorticoid receptor...

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Autores principales:	Minchenko D.O., Riabovol O.O., Tsymbal D.O., Ratushna O.O., Minchenko O.H.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	ire1 inhibition mrna expression nr3c1 sgk1 sgk3 ncoa2 arhgap35 nnt hypoxia u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/084224c2bc28455889aebc330c07e02a
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spelling	oai:doaj.org-article:084224c2bc28455889aebc330c07e02a2021-12-02T16:33:00ZInhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells1336-032910.1515/enr-2016-0014https://doaj.org/article/084224c2bc28455889aebc330c07e02a2016-07-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0014https://doaj.org/toc/1336-0329Objective. The aim of the present investigation was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of genes encoding glucocorticoid receptor (NR3C1) and some related proteins (SGK1, SGK3, NCOA1, NCOA2, ARHGAP35, NNT) and their hypoxic regulation in U87 glioma cells for evaluation of their possible significance in the control of the glioma growth.Minchenko D.O.Riabovol O.O.Tsymbal D.O.Ratushna O.O.Minchenko O.H.Sciendoarticleire1 inhibitionmrna expressionnr3c1sgk1sgk3ncoa2arhgap35nnthypoxiau87 glioma cellsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 3, Pp 127-136 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ire1 inhibition mrna expression nr3c1 sgk1 sgk3 ncoa2 arhgap35 nnt hypoxia u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	ire1 inhibition mrna expression nr3c1 sgk1 sgk3 ncoa2 arhgap35 nnt hypoxia u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665 Minchenko D.O. Riabovol O.O. Tsymbal D.O. Ratushna O.O. Minchenko O.H. Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
description	Objective. The aim of the present investigation was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of genes encoding glucocorticoid receptor (NR3C1) and some related proteins (SGK1, SGK3, NCOA1, NCOA2, ARHGAP35, NNT) and their hypoxic regulation in U87 glioma cells for evaluation of their possible significance in the control of the glioma growth.
format	article
author	Minchenko D.O. Riabovol O.O. Tsymbal D.O. Ratushna O.O. Minchenko O.H.
author_facet	Minchenko D.O. Riabovol O.O. Tsymbal D.O. Ratushna O.O. Minchenko O.H.
author_sort	Minchenko D.O.
title	Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
title_short	Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
title_full	Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
title_fullStr	Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
title_full_unstemmed	Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells
title_sort	inhibition of ire1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in u87 glioma cells
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/084224c2bc28455889aebc330c07e02a
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Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells

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