Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes

Yalamanchi Aiswarya, Channabasappa Shivaprasad, Kolly Anish, Atluri Sridevi, Biswas Anupam, Goel AmitDepartment of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IndiaBackground: Fibrocalculous pancreatic diabetes (FCPD) is a secondary form of diabetes seen in pa...

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Autores principales:	Aiswarya Y, Shivaprasad C, Anish K, Sridevi A, Anupam B, Amit G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	fibrocalculous pancreatic diabetes tropical chronic pancreatitis insulin resistance beta cell function HOMA-IR QUICKI Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0843720af03c4aef86cd0bdf44a43263
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spelling	oai:doaj.org-article:0843720af03c4aef86cd0bdf44a432632021-12-02T06:45:45ZAssessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes1178-7007https://doaj.org/article/0843720af03c4aef86cd0bdf44a432632019-05-01T00:00:00Zhttps://www.dovepress.com/assessment-of-insulin-sensitivity-and-secretion-in-patients-with-fibro-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yalamanchi Aiswarya, Channabasappa Shivaprasad, Kolly Anish, Atluri Sridevi, Biswas Anupam, Goel AmitDepartment of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IndiaBackground: Fibrocalculous pancreatic diabetes (FCPD) is a secondary form of diabetes seen in patients with tropical chronic pancreatitis. Insulin deficiency plays a major role in the etiopathogenesis of FCPD. Limited data suggest a possible role of insulin resistance (IR) in the pathogenesis of FCPD. Sparse data exist on measures of insulin sensitivity (IS) and secretion in patients with FCPD and its comparison to type 2 diabetes mellitus (T2D) patients.Method: Eighty patients with FCPD, 36 patients with T2D and 36 healthy subjects were included. A 75 g oral glucose tolerance test (OGTT) was performed in the morning after an overnight fast. We evaluated IS and secretion using indices derived from fasting (homeostasis model assessment of insulin resistance [HOMA-IR], quantitativeinsulin sensitivity check index [QUICKI] and homeostasis model assessment of beta-cell function [HOMA-ß]) and OGTT (Matsuda, insulin sensitivity index by Kanauchi [ISI-K], oral glucose insulin sensitivity index [OGIS], Stumvoll, insulinogenic index and oral disposition index [ODI]) measurements of glucose and insulin.Results: HOMA-IR was significantly higher and QUICKI significantly lower in patients with FCPD and T2D than in healthy controls (P<0.001). Matsuda, ISI-K, OGIS and Stumvoll were significantly lower in patients with FCPD and T2D than in healthy controls (P<0.001), indicating reduced IS in both FCPD and T2D patients. HOMA-ß, insulinogenic index and ODI were significantly lower in patients with FCPD and T2D compared to healthy controls (P<0.001).Conclusion: FCPD is associated with reduced IS as assessed by fasting and OGTT-based indices. FCPD is also associated with a greater degree of impairment in insulin secretion than in T2D. IR may play a role in the pathogenesis of FCPD.Keywords: fibrocalculous pancreatic diabetes, tropical chronic pancreatitis, insulin resistance, beta-cell function, HOMA-IR, QUICKIAiswarya YShivaprasad CAnish KSridevi AAnupam BAmit GDove Medical Pressarticlefibrocalculous pancreatic diabetestropical chronic pancreatitisinsulin resistancebeta cell functionHOMA-IRQUICKISpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 779-788 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrocalculous pancreatic diabetes tropical chronic pancreatitis insulin resistance beta cell function HOMA-IR QUICKI Specialties of internal medicine RC581-951
spellingShingle	fibrocalculous pancreatic diabetes tropical chronic pancreatitis insulin resistance beta cell function HOMA-IR QUICKI Specialties of internal medicine RC581-951 Aiswarya Y Shivaprasad C Anish K Sridevi A Anupam B Amit G Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
description	Yalamanchi Aiswarya, Channabasappa Shivaprasad, Kolly Anish, Atluri Sridevi, Biswas Anupam, Goel AmitDepartment of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IndiaBackground: Fibrocalculous pancreatic diabetes (FCPD) is a secondary form of diabetes seen in patients with tropical chronic pancreatitis. Insulin deficiency plays a major role in the etiopathogenesis of FCPD. Limited data suggest a possible role of insulin resistance (IR) in the pathogenesis of FCPD. Sparse data exist on measures of insulin sensitivity (IS) and secretion in patients with FCPD and its comparison to type 2 diabetes mellitus (T2D) patients.Method: Eighty patients with FCPD, 36 patients with T2D and 36 healthy subjects were included. A 75 g oral glucose tolerance test (OGTT) was performed in the morning after an overnight fast. We evaluated IS and secretion using indices derived from fasting (homeostasis model assessment of insulin resistance [HOMA-IR], quantitativeinsulin sensitivity check index [QUICKI] and homeostasis model assessment of beta-cell function [HOMA-ß]) and OGTT (Matsuda, insulin sensitivity index by Kanauchi [ISI-K], oral glucose insulin sensitivity index [OGIS], Stumvoll, insulinogenic index and oral disposition index [ODI]) measurements of glucose and insulin.Results: HOMA-IR was significantly higher and QUICKI significantly lower in patients with FCPD and T2D than in healthy controls (P<0.001). Matsuda, ISI-K, OGIS and Stumvoll were significantly lower in patients with FCPD and T2D than in healthy controls (P<0.001), indicating reduced IS in both FCPD and T2D patients. HOMA-ß, insulinogenic index and ODI were significantly lower in patients with FCPD and T2D compared to healthy controls (P<0.001).Conclusion: FCPD is associated with reduced IS as assessed by fasting and OGTT-based indices. FCPD is also associated with a greater degree of impairment in insulin secretion than in T2D. IR may play a role in the pathogenesis of FCPD.Keywords: fibrocalculous pancreatic diabetes, tropical chronic pancreatitis, insulin resistance, beta-cell function, HOMA-IR, QUICKI
format	article
author	Aiswarya Y Shivaprasad C Anish K Sridevi A Anupam B Amit G
author_facet	Aiswarya Y Shivaprasad C Anish K Sridevi A Anupam B Amit G
author_sort	Aiswarya Y
title	Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
title_short	Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
title_full	Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
title_fullStr	Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
title_full_unstemmed	Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
title_sort	assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0843720af03c4aef86cd0bdf44a43263
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Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes

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