Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves

In contrast with the brain and spinal cord, peripheral nerves possess a striking ability to regenerate after damage. This characteristic of the peripheral nervous system is mainly due to a specific population of glial cells, the Schwann cells. Schwann cells promptly activate after nerve injury, dedi...

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Autores principales:	Elena Pompili, Valerio De Franchis, Claudia Giampietri, Stefano Leone, Elena De Santis, Francesco Fornai, Lorenzo Fumagalli, Cinzia Fabrizi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thrombin protease-activated receptor PAR1 peripheral nerve regeneration Schwann cells Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0846d82e4e1f4376a0e17d5a5fc547e9
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spelling	oai:doaj.org-article:0846d82e4e1f4376a0e17d5a5fc547e92021-11-25T16:53:36ZProtease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves10.3390/biom111116682218-273Xhttps://doaj.org/article/0846d82e4e1f4376a0e17d5a5fc547e92021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1668https://doaj.org/toc/2218-273XIn contrast with the brain and spinal cord, peripheral nerves possess a striking ability to regenerate after damage. This characteristic of the peripheral nervous system is mainly due to a specific population of glial cells, the Schwann cells. Schwann cells promptly activate after nerve injury, dedifferentiate assuming a repair phenotype, and assist axon regrowth. In general, tissue injury determines the release of a variety of proteases which, in parallel with the degradation of their specific targets, also activate plasma membrane receptors known as protease-activated receptors (PARs). PAR1, the prototypical member of the PAR family, is also known as thrombin receptor and is present at the Schwann cell plasma membrane. This receptor is emerging as a possible regulator of the pro-regenerative capacity of Schwann cells. Here, we summarize the most recent literature data describing the possible contribution of PAR1 and PAR1-activating proteases in regulating the regeneration of peripheral nerves.Elena PompiliValerio De FranchisClaudia GiampietriStefano LeoneElena De SantisFrancesco FornaiLorenzo FumagalliCinzia FabriziMDPI AGarticlethrombinprotease-activated receptorPAR1peripheral nerveregenerationSchwann cellsMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1668, p 1668 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thrombin protease-activated receptor PAR1 peripheral nerve regeneration Schwann cells Microbiology QR1-502
spellingShingle	thrombin protease-activated receptor PAR1 peripheral nerve regeneration Schwann cells Microbiology QR1-502 Elena Pompili Valerio De Franchis Claudia Giampietri Stefano Leone Elena De Santis Francesco Fornai Lorenzo Fumagalli Cinzia Fabrizi Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
description	In contrast with the brain and spinal cord, peripheral nerves possess a striking ability to regenerate after damage. This characteristic of the peripheral nervous system is mainly due to a specific population of glial cells, the Schwann cells. Schwann cells promptly activate after nerve injury, dedifferentiate assuming a repair phenotype, and assist axon regrowth. In general, tissue injury determines the release of a variety of proteases which, in parallel with the degradation of their specific targets, also activate plasma membrane receptors known as protease-activated receptors (PARs). PAR1, the prototypical member of the PAR family, is also known as thrombin receptor and is present at the Schwann cell plasma membrane. This receptor is emerging as a possible regulator of the pro-regenerative capacity of Schwann cells. Here, we summarize the most recent literature data describing the possible contribution of PAR1 and PAR1-activating proteases in regulating the regeneration of peripheral nerves.
format	article
author	Elena Pompili Valerio De Franchis Claudia Giampietri Stefano Leone Elena De Santis Francesco Fornai Lorenzo Fumagalli Cinzia Fabrizi
author_facet	Elena Pompili Valerio De Franchis Claudia Giampietri Stefano Leone Elena De Santis Francesco Fornai Lorenzo Fumagalli Cinzia Fabrizi
author_sort	Elena Pompili
title	Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
title_short	Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
title_full	Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
title_fullStr	Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
title_full_unstemmed	Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
title_sort	protease activated receptor 1 and its ligands as main regulators of the regeneration of peripheral nerves
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0846d82e4e1f4376a0e17d5a5fc547e9
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Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves

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