H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.

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Autores principales:	Xian Zhang, Binkui Li, Abdol Hossein Rezaeian, Xiaohong Xu, Ping-Chieh Chou, Guoxiang Jin, Fei Han, Bo-Syong Pan, Chi-Yun Wang, Jie Long, Anmei Zhang, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Christopher Logothetis, Hui-Kuan Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08472bddebdd4affaebf25d8c71e5057
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spelling	oai:doaj.org-article:08472bddebdd4affaebf25d8c71e50572021-12-02T14:41:09ZH3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis10.1038/ncomms147992041-1723https://doaj.org/article/08472bddebdd4affaebf25d8c71e50572017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14799https://doaj.org/toc/2041-1723Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.Xian ZhangBinkui LiAbdol Hossein RezaeianXiaohong XuPing-Chieh ChouGuoxiang JinFei HanBo-Syong PanChi-Yun WangJie LongAnmei ZhangChih-Yang HuangFuu-Jen TsaiChang-Hai TsaiChristopher LogothetisHui-Kuan LinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xian Zhang Binkui Li Abdol Hossein Rezaeian Xiaohong Xu Ping-Chieh Chou Guoxiang Jin Fei Han Bo-Syong Pan Chi-Yun Wang Jie Long Anmei Zhang Chih-Yang Huang Fuu-Jen Tsai Chang-Hai Tsai Christopher Logothetis Hui-Kuan Lin H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
description	Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.
format	article
author	Xian Zhang Binkui Li Abdol Hossein Rezaeian Xiaohong Xu Ping-Chieh Chou Guoxiang Jin Fei Han Bo-Syong Pan Chi-Yun Wang Jie Long Anmei Zhang Chih-Yang Huang Fuu-Jen Tsai Chang-Hai Tsai Christopher Logothetis Hui-Kuan Lin
author_facet	Xian Zhang Binkui Li Abdol Hossein Rezaeian Xiaohong Xu Ping-Chieh Chou Guoxiang Jin Fei Han Bo-Syong Pan Chi-Yun Wang Jie Long Anmei Zhang Chih-Yang Huang Fuu-Jen Tsai Chang-Hai Tsai Christopher Logothetis Hui-Kuan Lin
author_sort	Xian Zhang
title	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
title_short	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
title_full	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
title_fullStr	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
title_full_unstemmed	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
title_sort	h3 ubiquitination by nedd4 regulates h3 acetylation and tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/08472bddebdd4affaebf25d8c71e5057
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_version_	1718389972088651776

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

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