Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

Excess antigenic exposure, such as in cancers or chronic viral infection, can lead to T cell exhaustion. Here the authors show that despite high exposure to antigen in the context of chronic LCMV infection in mice, exhausted CD8+ T cells have low levels of TCR signalling that can be reactivated by P...

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Autores principales:	Ioana Sandu, Dario Cerletti, Manfred Claassen, Annette Oxenius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0847b4efc9ab451ba66c78afdb12de6e
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spelling	oai:doaj.org-article:0847b4efc9ab451ba66c78afdb12de6e2021-12-02T18:03:07ZExhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection10.1038/s41467-020-18256-42041-1723https://doaj.org/article/0847b4efc9ab451ba66c78afdb12de6e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18256-4https://doaj.org/toc/2041-1723Excess antigenic exposure, such as in cancers or chronic viral infection, can lead to T cell exhaustion. Here the authors show that despite high exposure to antigen in the context of chronic LCMV infection in mice, exhausted CD8+ T cells have low levels of TCR signalling that can be reactivated by PD-L1 blockade.Ioana SanduDario CerlettiManfred ClaassenAnnette OxeniusNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ioana Sandu Dario Cerletti Manfred Claassen Annette Oxenius Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
description	Excess antigenic exposure, such as in cancers or chronic viral infection, can lead to T cell exhaustion. Here the authors show that despite high exposure to antigen in the context of chronic LCMV infection in mice, exhausted CD8+ T cells have low levels of TCR signalling that can be reactivated by PD-L1 blockade.
format	article
author	Ioana Sandu Dario Cerletti Manfred Claassen Annette Oxenius
author_facet	Ioana Sandu Dario Cerletti Manfred Claassen Annette Oxenius
author_sort	Ioana Sandu
title	Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
title_short	Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
title_full	Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
title_fullStr	Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
title_full_unstemmed	Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
title_sort	exhausted cd8+ t cells exhibit low and strongly inhibited tcr signaling during chronic lcmv infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0847b4efc9ab451ba66c78afdb12de6e
work_keys_str_mv	AT ioanasandu exhaustedcd8tcellsexhibitlowandstronglyinhibitedtcrsignalingduringchroniclcmvinfection AT dariocerletti exhaustedcd8tcellsexhibitlowandstronglyinhibitedtcrsignalingduringchroniclcmvinfection AT manfredclaassen exhaustedcd8tcellsexhibitlowandstronglyinhibitedtcrsignalingduringchroniclcmvinfection AT annetteoxenius exhaustedcd8tcellsexhibitlowandstronglyinhibitedtcrsignalingduringchroniclcmvinfection
_version_	1718378790633078784

Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

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