Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.

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Autores principales: Melanie Werner-Klein, Sebastian Scheitler, Martin Hoffmann, Isabelle Hodak, Klaus Dietz, Petra Lehnert, Veronika Naimer, Bernhard Polzer, Steffi Treitschke, Christian Werno, Aleksandra Markiewicz, Kathrin Weidele, Zbigniew Czyz, Ulrich Hohenleutner, Christian Hafner, Sebastian Haferkamp, Mark Berneburg, Petra Rümmele, Anja Ulmer, Christoph A. Klein
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/08484ba36c924d67bd84ae818b551c58
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spelling oai:doaj.org-article:08484ba36c924d67bd84ae818b551c582021-12-02T14:39:27ZGenetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma10.1038/s41467-017-02674-y2041-1723https://doaj.org/article/08484ba36c924d67bd84ae818b551c582018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02674-yhttps://doaj.org/toc/2041-1723For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.Melanie Werner-KleinSebastian ScheitlerMartin HoffmannIsabelle HodakKlaus DietzPetra LehnertVeronika NaimerBernhard PolzerSteffi TreitschkeChristian WernoAleksandra MarkiewiczKathrin WeideleZbigniew CzyzUlrich HohenleutnerChristian HafnerSebastian HaferkampMark BerneburgPetra RümmeleAnja UlmerChristoph A. KleinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Melanie Werner-Klein
Sebastian Scheitler
Martin Hoffmann
Isabelle Hodak
Klaus Dietz
Petra Lehnert
Veronika Naimer
Bernhard Polzer
Steffi Treitschke
Christian Werno
Aleksandra Markiewicz
Kathrin Weidele
Zbigniew Czyz
Ulrich Hohenleutner
Christian Hafner
Sebastian Haferkamp
Mark Berneburg
Petra Rümmele
Anja Ulmer
Christoph A. Klein
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
description For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.
format article
author Melanie Werner-Klein
Sebastian Scheitler
Martin Hoffmann
Isabelle Hodak
Klaus Dietz
Petra Lehnert
Veronika Naimer
Bernhard Polzer
Steffi Treitschke
Christian Werno
Aleksandra Markiewicz
Kathrin Weidele
Zbigniew Czyz
Ulrich Hohenleutner
Christian Hafner
Sebastian Haferkamp
Mark Berneburg
Petra Rümmele
Anja Ulmer
Christoph A. Klein
author_facet Melanie Werner-Klein
Sebastian Scheitler
Martin Hoffmann
Isabelle Hodak
Klaus Dietz
Petra Lehnert
Veronika Naimer
Bernhard Polzer
Steffi Treitschke
Christian Werno
Aleksandra Markiewicz
Kathrin Weidele
Zbigniew Czyz
Ulrich Hohenleutner
Christian Hafner
Sebastian Haferkamp
Mark Berneburg
Petra Rümmele
Anja Ulmer
Christoph A. Klein
author_sort Melanie Werner-Klein
title Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
title_short Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
title_full Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
title_fullStr Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
title_full_unstemmed Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
title_sort genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/08484ba36c924d67bd84ae818b551c58
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