Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.
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Nature Portfolio
2018
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oai:doaj.org-article:08484ba36c924d67bd84ae818b551c582021-12-02T14:39:27ZGenetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma10.1038/s41467-017-02674-y2041-1723https://doaj.org/article/08484ba36c924d67bd84ae818b551c582018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02674-yhttps://doaj.org/toc/2041-1723For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.Melanie Werner-KleinSebastian ScheitlerMartin HoffmannIsabelle HodakKlaus DietzPetra LehnertVeronika NaimerBernhard PolzerSteffi TreitschkeChristian WernoAleksandra MarkiewiczKathrin WeideleZbigniew CzyzUlrich HohenleutnerChristian HafnerSebastian HaferkampMark BerneburgPetra RümmeleAnja UlmerChristoph A. KleinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
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spellingShingle |
Science Q Melanie Werner-Klein Sebastian Scheitler Martin Hoffmann Isabelle Hodak Klaus Dietz Petra Lehnert Veronika Naimer Bernhard Polzer Steffi Treitschke Christian Werno Aleksandra Markiewicz Kathrin Weidele Zbigniew Czyz Ulrich Hohenleutner Christian Hafner Sebastian Haferkamp Mark Berneburg Petra Rümmele Anja Ulmer Christoph A. Klein Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
description |
For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites. |
format |
article |
author |
Melanie Werner-Klein Sebastian Scheitler Martin Hoffmann Isabelle Hodak Klaus Dietz Petra Lehnert Veronika Naimer Bernhard Polzer Steffi Treitschke Christian Werno Aleksandra Markiewicz Kathrin Weidele Zbigniew Czyz Ulrich Hohenleutner Christian Hafner Sebastian Haferkamp Mark Berneburg Petra Rümmele Anja Ulmer Christoph A. Klein |
author_facet |
Melanie Werner-Klein Sebastian Scheitler Martin Hoffmann Isabelle Hodak Klaus Dietz Petra Lehnert Veronika Naimer Bernhard Polzer Steffi Treitschke Christian Werno Aleksandra Markiewicz Kathrin Weidele Zbigniew Czyz Ulrich Hohenleutner Christian Hafner Sebastian Haferkamp Mark Berneburg Petra Rümmele Anja Ulmer Christoph A. Klein |
author_sort |
Melanie Werner-Klein |
title |
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
title_short |
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
title_full |
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
title_fullStr |
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
title_full_unstemmed |
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
title_sort |
genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/08484ba36c924d67bd84ae818b551c58 |
work_keys_str_mv |
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1718390575315550208 |