A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.

A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.

Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroe...

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Auteurs principaux: Jian Luo, Gayathri Swaminath, Sean P Brown, Jane Zhang, Qi Guo, Michael Chen, Kathy Nguyen, Thanhvien Tran, Lynn Miao, Paul J Dransfield, Marc Vimolratana, Jonathan B Houze, Simon Wong, Maria Toteva, Bei Shan, Frank Li, Run Zhuang, Daniel C-H Lin
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/0849b9dfe7b244fab2862894d2869154
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https://doaj.org/article/0849b9dfe7b244fab2862894d2869154

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