Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes

Beth Faiman, Jason Valent Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA Abstract: Improved understanding as to the biology of multiple myeloma (MM) and the bone marrow microenvironment has led to the development of new drugs to...

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Autores principales:	Faiman B, Valent J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Multiple Myeloma monitoring survivorship side effect management Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/0849c85822d74002822d0eaab3b3a1d7
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spelling	oai:doaj.org-article:0849c85822d74002822d0eaab3b3a1d72021-12-02T08:38:25ZAssessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes1179-9889https://doaj.org/article/0849c85822d74002822d0eaab3b3a1d72016-05-01T00:00:00Zhttps://www.dovepress.com/assessment-and-monitoring-of-patients-receiving-chemotherapy-for-multi-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889Beth Faiman, Jason Valent Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA Abstract: Improved understanding as to the biology of multiple myeloma (MM) and the bone marrow microenvironment has led to the development of new drugs to treat MM. This explosion of new and highly effective drugs has led to dramatic advances in the management of MM and underscores the need for supportive care. Impressive and deep response rates to chemotherapy, monoclonal antibodies, and small molecule drugs provide hope of a cure or prolonged remission for the majority of individuals. For most patients, long-term, continuous therapy is often required to suppress the malignant plasma cell clone, thus requiring clinicians to become more astute in assessment, monitoring, and intervention of side effects as well as monitoring response to therapy. Appropriate diagnosis and monitoring strategies are essential to ensure that patients receive the appropriate chemotherapy and supportive therapy at relapse, and that side effects are appropriately managed to allow for continued therapy and adherence to the regimen. Multiple drugs with complex regimens are currently available with varying side effect profiles. Knowledge of the drugs used to treat MM and the common adverse events will allow for preventative strategies to mitigate adverse events and prompt intervention. The purpose of this paper is to review updates in the diagnosis and management of MM, and to provide strategies for assessment and monitoring of patients receiving chemotherapy for MM. Keywords: multiple myeloma, treatment, symptoms, assessment, monitoring, symptom management, targeted therapiesFaiman BValent JDove Medical PressarticleMultiple Myelomamonitoringsurvivorshipside effect managementDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 21-35 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple Myeloma monitoring survivorship side effect management Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Multiple Myeloma monitoring survivorship side effect management Diseases of the blood and blood-forming organs RC633-647.5 Faiman B Valent J Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
description	Beth Faiman, Jason Valent Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA Abstract: Improved understanding as to the biology of multiple myeloma (MM) and the bone marrow microenvironment has led to the development of new drugs to treat MM. This explosion of new and highly effective drugs has led to dramatic advances in the management of MM and underscores the need for supportive care. Impressive and deep response rates to chemotherapy, monoclonal antibodies, and small molecule drugs provide hope of a cure or prolonged remission for the majority of individuals. For most patients, long-term, continuous therapy is often required to suppress the malignant plasma cell clone, thus requiring clinicians to become more astute in assessment, monitoring, and intervention of side effects as well as monitoring response to therapy. Appropriate diagnosis and monitoring strategies are essential to ensure that patients receive the appropriate chemotherapy and supportive therapy at relapse, and that side effects are appropriately managed to allow for continued therapy and adherence to the regimen. Multiple drugs with complex regimens are currently available with varying side effect profiles. Knowledge of the drugs used to treat MM and the common adverse events will allow for preventative strategies to mitigate adverse events and prompt intervention. The purpose of this paper is to review updates in the diagnosis and management of MM, and to provide strategies for assessment and monitoring of patients receiving chemotherapy for MM. Keywords: multiple myeloma, treatment, symptoms, assessment, monitoring, symptom management, targeted therapies
format	article
author	Faiman B Valent J
author_facet	Faiman B Valent J
author_sort	Faiman B
title	Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
title_short	Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
title_full	Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
title_fullStr	Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
title_full_unstemmed	Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
title_sort	assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0849c85822d74002822d0eaab3b3a1d7
work_keys_str_mv	AT faimanb assessmentandmonitoringofpatientsreceivingchemotherapyformultiplemyelomastrategiestoimproveoutcomes AT valentj assessmentandmonitoringofpatientsreceivingchemotherapyformultiplemyelomastrategiestoimproveoutcomes
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Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes

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