High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion

Development of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients...

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Autores principales:	Ricardo Rivera-López, Celia García-López, José M. Sánchez-Moreno, Rafael A. Rivera-López, Julio Almansa-López, Ricardo Rivera-Fernández, Eduardo Molina-Navarro, Miriam Jiménez-Fernández, Santiago Ortiz-Pérez, José A. Ramírez-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cataracts ionizing radiation chronic coronary total occlusion percutaneous coronary intervention Medicine R
Acceso en línea:	https://doaj.org/article/084c2bbfe1494261aaad7ddabd591c11
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spelling	oai:doaj.org-article:084c2bbfe1494261aaad7ddabd591c112021-11-11T17:38:08ZHigh Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion10.3390/jcm102150022077-0383https://doaj.org/article/084c2bbfe1494261aaad7ddabd591c112021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5002https://doaj.org/toc/2077-0383Development of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients undergoing percutaneous coronary intervention (PCI) for chronic coronary total occlusion (CTO) and its association with radiation dose. The study analyzed the incidence of cataracts during the follow-up of 126 patients who underwent chronic total coronary PCI, using Cox regression to identify predictive factors of cataract development. The study included 126 patients, 86.9% male, with a mean age of 60.5 years (range, 55.0–68.0 years). Twenty-three (18.2% <i>n</i> = 23) developed cataracts during a mean follow-up of 49.5 months (range 37.3–64.5 months). A higher incidence was observed in patients who received more than 5 Gy (29.0% vs. 14.7%, Hazard ratio (HR = 2.84 [1.19–6.77]). Multivariate analysis revealed a relationship between cataract development during the follow-up and a receipt of radiation dose >5 Gy (HR = 2.60, 95% confidence interval [CI 1.03–6.61]; <i>p</i> = 0.03), presence or history of predisposing eye disease (HR = 4.42, CI:1.57–12.40), diabetes (HR = 3.33 [1.22–9.24]), and older age, as in >57 (HR, 6.40 [1.81–22.61]). An elevated incidence of cataracts was observed in patients after PCI for CTO. The onset of cataracts is related to the radiation dose during catheterization, which is a potentially avoidable effect of which operators should be aware.Ricardo Rivera-LópezCelia García-LópezJosé M. Sánchez-MorenoRafael A. Rivera-LópezJulio Almansa-LópezRicardo Rivera-FernándezEduardo Molina-NavarroMiriam Jiménez-FernándezSantiago Ortiz-PérezJosé A. Ramírez-HernándezMDPI AGarticlecataractsionizing radiationchronic coronary total occlusionpercutaneous coronary interventionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5002, p 5002 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cataracts ionizing radiation chronic coronary total occlusion percutaneous coronary intervention Medicine R
spellingShingle	cataracts ionizing radiation chronic coronary total occlusion percutaneous coronary intervention Medicine R Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
description	Development of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients undergoing percutaneous coronary intervention (PCI) for chronic coronary total occlusion (CTO) and its association with radiation dose. The study analyzed the incidence of cataracts during the follow-up of 126 patients who underwent chronic total coronary PCI, using Cox regression to identify predictive factors of cataract development. The study included 126 patients, 86.9% male, with a mean age of 60.5 years (range, 55.0–68.0 years). Twenty-three (18.2% <i>n</i> = 23) developed cataracts during a mean follow-up of 49.5 months (range 37.3–64.5 months). A higher incidence was observed in patients who received more than 5 Gy (29.0% vs. 14.7%, Hazard ratio (HR = 2.84 [1.19–6.77]). Multivariate analysis revealed a relationship between cataract development during the follow-up and a receipt of radiation dose >5 Gy (HR = 2.60, 95% confidence interval [CI 1.03–6.61]; <i>p</i> = 0.03), presence or history of predisposing eye disease (HR = 4.42, CI:1.57–12.40), diabetes (HR = 3.33 [1.22–9.24]), and older age, as in >57 (HR, 6.40 [1.81–22.61]). An elevated incidence of cataracts was observed in patients after PCI for CTO. The onset of cataracts is related to the radiation dose during catheterization, which is a potentially avoidable effect of which operators should be aware.
format	article
author	Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández
author_facet	Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández
author_sort	Ricardo Rivera-López
title	High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
title_short	High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
title_full	High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
title_fullStr	High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
title_full_unstemmed	High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
title_sort	high incidence of cataracts in the follow-up of patients undergoing percutaneous coronary intervention for chronic coronary total occlusion
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/084c2bbfe1494261aaad7ddabd591c11
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High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion

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