Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1...

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Autores principales:	Kazuya Ono, James Keller, Omar López Ramírez, Antonia González Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/084c5655bae6444e9673319881b6fdc4
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spelling	oai:doaj.org-article:084c5655bae6444e9673319881b6fdc42021-12-02T14:42:11ZRetinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations10.1038/s41467-019-13710-42041-1723https://doaj.org/article/084c5655bae6444e9673319881b6fdc42020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13710-4https://doaj.org/toc/2041-1723The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1 cKO mice have abnormal vestibular evoked potentials and balance beam performance, but normal vestibular-ocular reflexes.Kazuya OnoJames KellerOmar López RamírezAntonia González GarridoOmid A. ZobeiriHui Ho Vanessa ChangSarath VijayakumarAndrianna AyiotisGregg DuesterCharles C. Della SantinaSherri M. JonesKathleen E. CullenRuth Anne EatockDoris K. WuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuya Ono James Keller Omar López Ramírez Antonia González Garrido Omid A. Zobeiri Hui Ho Vanessa Chang Sarath Vijayakumar Andrianna Ayiotis Gregg Duester Charles C. Della Santina Sherri M. Jones Kathleen E. Cullen Ruth Anne Eatock Doris K. Wu Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
description	The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1 cKO mice have abnormal vestibular evoked potentials and balance beam performance, but normal vestibular-ocular reflexes.
format	article
author	Kazuya Ono James Keller Omar López Ramírez Antonia González Garrido Omid A. Zobeiri Hui Ho Vanessa Chang Sarath Vijayakumar Andrianna Ayiotis Gregg Duester Charles C. Della Santina Sherri M. Jones Kathleen E. Cullen Ruth Anne Eatock Doris K. Wu
author_facet	Kazuya Ono James Keller Omar López Ramírez Antonia González Garrido Omid A. Zobeiri Hui Ho Vanessa Chang Sarath Vijayakumar Andrianna Ayiotis Gregg Duester Charles C. Della Santina Sherri M. Jones Kathleen E. Cullen Ruth Anne Eatock Doris K. Wu
author_sort	Kazuya Ono
title	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
title_short	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
title_full	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
title_fullStr	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
title_full_unstemmed	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
title_sort	retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/084c5655bae6444e9673319881b6fdc4
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Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

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