Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.

<h4>Objective</h4>Impulse control disorders (ICDs) and dopamine dysregulation syndrome (DDS) are important behavioral problems that affect a subpopulation of patients with Parkinson's disease (PD) and typically result in markedly diminished quality of life for patients and their car...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah J Moum, Catherine C Price, Natlada Limotai, Genko Oyama, Herbert Ward, Charles Jacobson, Kelly D Foote, Michael S Okun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/084dac87aef94e2cbfc757f5faeb1bc1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:084dac87aef94e2cbfc757f5faeb1bc1
record_format	dspace
spelling	oai:doaj.org-article:084dac87aef94e2cbfc757f5faeb1bc12021-11-18T07:29:23ZEffects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.1932-620310.1371/journal.pone.0029768https://doaj.org/article/084dac87aef94e2cbfc757f5faeb1bc12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22295068/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Impulse control disorders (ICDs) and dopamine dysregulation syndrome (DDS) are important behavioral problems that affect a subpopulation of patients with Parkinson's disease (PD) and typically result in markedly diminished quality of life for patients and their caregivers. We aimed to investigate the effects of subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) on ICD/DDS frequency and dopaminergic medication usage.<h4>Methods</h4>A retrospective chart review was performed on 159 individuals who underwent unilateral or bilateral PD DBS surgery in either STN or GPi. According to published criteria, pre- and post-operative records were reviewed to categorize patients both pre- and post-operatively as having ICD, DDS, both ICD and DDS, or neither ICD nor DDS. Group differences in patient demographics, clinical presentations, levodopa equivalent dose (LED), and change in diagnosis following unilateral/bilateral by brain target (STN or GPi DBS placement) were examined.<h4>Results</h4>28 patients met diagnostic criteria for ICD or DDS pre- or post-operatively. ICD or DDS classification did not differ by GPi or STN target stimulation. There was no change in DDS diagnosis after unilateral or bilateral stimulation. For ICD, diagnosis resolved in 2 of 7 individuals after unilateral or bilateral DBS. Post-operative development of these syndromes was significant; 17 patients developed ICD diagnoses post-operatively with 2 patients with pre-operative ICD developing DDS post-operatively.<h4>Conclusions</h4>Unilateral or bilateral DBS did not significantly treat DDS or ICD in our sample, even though a few cases of ICD resolved post-operatively. Rather, our study provides preliminary evidence that DDS and ICD diagnoses may emerge following DBS surgery.Sarah J MoumCatherine C PriceNatlada LimotaiGenko OyamaHerbert WardCharles JacobsonKelly D FooteMichael S OkunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29768 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah J Moum Catherine C Price Natlada Limotai Genko Oyama Herbert Ward Charles Jacobson Kelly D Foote Michael S Okun Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
description	<h4>Objective</h4>Impulse control disorders (ICDs) and dopamine dysregulation syndrome (DDS) are important behavioral problems that affect a subpopulation of patients with Parkinson's disease (PD) and typically result in markedly diminished quality of life for patients and their caregivers. We aimed to investigate the effects of subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) on ICD/DDS frequency and dopaminergic medication usage.<h4>Methods</h4>A retrospective chart review was performed on 159 individuals who underwent unilateral or bilateral PD DBS surgery in either STN or GPi. According to published criteria, pre- and post-operative records were reviewed to categorize patients both pre- and post-operatively as having ICD, DDS, both ICD and DDS, or neither ICD nor DDS. Group differences in patient demographics, clinical presentations, levodopa equivalent dose (LED), and change in diagnosis following unilateral/bilateral by brain target (STN or GPi DBS placement) were examined.<h4>Results</h4>28 patients met diagnostic criteria for ICD or DDS pre- or post-operatively. ICD or DDS classification did not differ by GPi or STN target stimulation. There was no change in DDS diagnosis after unilateral or bilateral stimulation. For ICD, diagnosis resolved in 2 of 7 individuals after unilateral or bilateral DBS. Post-operative development of these syndromes was significant; 17 patients developed ICD diagnoses post-operatively with 2 patients with pre-operative ICD developing DDS post-operatively.<h4>Conclusions</h4>Unilateral or bilateral DBS did not significantly treat DDS or ICD in our sample, even though a few cases of ICD resolved post-operatively. Rather, our study provides preliminary evidence that DDS and ICD diagnoses may emerge following DBS surgery.
format	article
author	Sarah J Moum Catherine C Price Natlada Limotai Genko Oyama Herbert Ward Charles Jacobson Kelly D Foote Michael S Okun
author_facet	Sarah J Moum Catherine C Price Natlada Limotai Genko Oyama Herbert Ward Charles Jacobson Kelly D Foote Michael S Okun
author_sort	Sarah J Moum
title	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
title_short	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
title_full	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
title_fullStr	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
title_full_unstemmed	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
title_sort	effects of stn and gpi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/084dac87aef94e2cbfc757f5faeb1bc1
work_keys_str_mv	AT sarahjmoum effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT catherinecprice effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT natladalimotai effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT genkooyama effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT herbertward effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT charlesjacobson effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT kellydfoote effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome AT michaelsokun effectsofstnandgpideepbrainstimulationonimpulsecontroldisordersanddopaminedysregulationsyndrome
_version_	1718423328997244928

Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome.

Ejemplares similares