The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma

The aim of this study was to investigate the plasma levels of interleukin-6, tumor necrosisfactor-α, immunoglobulin E, eosinophil cationic protein, thiobarbituric acid reactivesubstance and total antioxidant status which were suggested to have a significant rolein the pathogenesis of asthma in child...

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Autores principales:	A.Görkem Mungan, Berrak Güven, Murat Can, Gonca H. Üstündağ, Birol Yüksel, Tunç Tuncer, Selda Demirtaş, Nazan Tomaç
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2007
Materias:	Asthma Steroid treatment Oxidant-antioxidant system Cytokine Eosinophil cationic protein Thiobarbituric acid reactive substance Total antioxidant status Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/084f373d71834a03a2ba44248ba736cb
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spelling	oai:doaj.org-article:084f373d71834a03a2ba44248ba736cb2021-12-02T15:57:15ZThe Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma0250-46851303-829Xhttps://doaj.org/article/084f373d71834a03a2ba44248ba736cb2007-07-01T00:00:00Zhttp://www.TurkJBiochem.com/2007/055.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XThe aim of this study was to investigate the plasma levels of interleukin-6, tumor necrosisfactor-α, immunoglobulin E, eosinophil cationic protein, thiobarbituric acid reactivesubstance and total antioxidant status which were suggested to have a significant rolein the pathogenesis of asthma in children and to evaluate the effect of steroid on theseparameters. 27 children, mean aged 8.9 years with mild-moderate persistent asthma forthe study group and 25 healthy children, mean aged 10.3 years for the control groupare included in the study group. The symptom score, respiratory function test, plasmaimmunoglobulin E, eosinophil cationic protein, interleukin-6, tumor necrosis factor-α,thiobarbituric acid reactive substance and total antioxidant status levels were measuredin the study group before and 4 weeks after budenoside treatment and compared withthe control group. The tumor necrosis factor-α, thiobarbituric acid reactive substance,immunoglobulin E and eosinophil cationic protein levels measured before treatmentwere significantly higher than those of the control group. Although a significantdecrease was observed in thiobarbituric acid reactive substance, eosinophil cationicprotein and immunoglobulin E levels after inhaled steroid treatment, the interleukin-6,tumor necrosis factor-α and total antioxidant status levels showed no difference. Thetumor necrosis factor-α, immunoglobulin E and eosinophil cationic protein levels aftertreatment were significantly higher than those of the control group. In conclusion, weobserved that budenoside treatment in mild to moderate stable asthmatic children hadno direct effect on oxidant stress, antioxidant defense, interleukin-6 and tumor necrosisfactor-α. These results lead us to the decision that the steroidal treatment may achievea clinical improvement mainly by decreasing the levels of immunoglobulin E andeosinophil cationic protein.A.Görkem MunganBerrak GüvenMurat CanGonca H. ÜstündağBirol Yüksel,Tunç TuncerSelda DemirtaşNazan TomaçDe GruyterarticleAsthmaSteroid treatmentOxidant-antioxidant systemCytokineEosinophil cationic proteinThiobarbituric acid reactive substanceTotal antioxidant statusBiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 32, Iss 2, Pp 55-60 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Steroid treatment Oxidant-antioxidant system Cytokine Eosinophil cationic protein Thiobarbituric acid reactive substance Total antioxidant status Biochemistry QD415-436
spellingShingle	Asthma Steroid treatment Oxidant-antioxidant system Cytokine Eosinophil cationic protein Thiobarbituric acid reactive substance Total antioxidant status Biochemistry QD415-436 A.Görkem Mungan Berrak Güven Murat Can Gonca H. Üstündağ Birol Yüksel, Tunç Tuncer Selda Demirtaş Nazan Tomaç The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
description	The aim of this study was to investigate the plasma levels of interleukin-6, tumor necrosisfactor-α, immunoglobulin E, eosinophil cationic protein, thiobarbituric acid reactivesubstance and total antioxidant status which were suggested to have a significant rolein the pathogenesis of asthma in children and to evaluate the effect of steroid on theseparameters. 27 children, mean aged 8.9 years with mild-moderate persistent asthma forthe study group and 25 healthy children, mean aged 10.3 years for the control groupare included in the study group. The symptom score, respiratory function test, plasmaimmunoglobulin E, eosinophil cationic protein, interleukin-6, tumor necrosis factor-α,thiobarbituric acid reactive substance and total antioxidant status levels were measuredin the study group before and 4 weeks after budenoside treatment and compared withthe control group. The tumor necrosis factor-α, thiobarbituric acid reactive substance,immunoglobulin E and eosinophil cationic protein levels measured before treatmentwere significantly higher than those of the control group. Although a significantdecrease was observed in thiobarbituric acid reactive substance, eosinophil cationicprotein and immunoglobulin E levels after inhaled steroid treatment, the interleukin-6,tumor necrosis factor-α and total antioxidant status levels showed no difference. Thetumor necrosis factor-α, immunoglobulin E and eosinophil cationic protein levels aftertreatment were significantly higher than those of the control group. In conclusion, weobserved that budenoside treatment in mild to moderate stable asthmatic children hadno direct effect on oxidant stress, antioxidant defense, interleukin-6 and tumor necrosisfactor-α. These results lead us to the decision that the steroidal treatment may achievea clinical improvement mainly by decreasing the levels of immunoglobulin E andeosinophil cationic protein.
format	article
author	A.Görkem Mungan Berrak Güven Murat Can Gonca H. Üstündağ Birol Yüksel, Tunç Tuncer Selda Demirtaş Nazan Tomaç
author_facet	A.Görkem Mungan Berrak Güven Murat Can Gonca H. Üstündağ Birol Yüksel, Tunç Tuncer Selda Demirtaş Nazan Tomaç
author_sort	A.Görkem Mungan
title	The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
title_short	The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
title_full	The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
title_fullStr	The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
title_full_unstemmed	The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma
title_sort	effect of steroid treatment on serum oxidant-antioxidant system and cytokine levels in childhood asthma
publisher	De Gruyter
publishDate	2007
url	https://doaj.org/article/084f373d71834a03a2ba44248ba736cb
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The Effect of Steroid Treatment on Serum Oxidant-Antioxidant System and Cytokine Levels in Childhood Asthma

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