Peripheral surgical wounding and age-dependent neuroinflammation in mice.

Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to contribute to cognitive dysfunction in humans and cognitive impairment in anima...

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Autores principales:	Zhipeng Xu, Yuanlin Dong, Hui Wang, Deborah J Culley, Edward R Marcantonio, Gregory Crosby, Rudolph E Tanzi, Yiying Zhang, Zhongcong Xie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/084fbe7d7577401bb310bf808e3fd482
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spelling	oai:doaj.org-article:084fbe7d7577401bb310bf808e3fd4822021-11-18T08:20:53ZPeripheral surgical wounding and age-dependent neuroinflammation in mice.1932-620310.1371/journal.pone.0096752https://doaj.org/article/084fbe7d7577401bb310bf808e3fd4822014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24796537/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to contribute to cognitive dysfunction in humans and cognitive impairment in animals. Our recent studies have established a pre-clinical model in mice, and have found that the peripheral surgical wounding without the influence of general anesthesia induces an age-dependent Aβ accumulation and cognitive impairment in mice. We therefore set out to assess the effects of peripheral surgical wounding, in the absence of general anesthesia, on neuroinflammation in mice with different ages. Abdominal surgery under local anesthesia was established in 9 and 18 month-old mice. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), Iba1 positive cells (the marker of microglia activation), CD33, and cognitive function in mice were determined. The peripheral surgical wounding increased the levels of TNF-α, IL-6, and Iba1 positive cells in the hippocampus of both 9 and 18 month-old mice, and age potentiated these effects. The peripheral surgical wounding increased the levels of CD33 in the hippocampus of 18, but not 9, month-old mice. Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice. These data suggested that the peripheral surgical wounding could induce an age-dependent neuroinflammation and elevation of CD33 levels in the hippocampus of mice, which could lead to cognitive impairment in aged mice. Pending further studies, anti-inflammatory therapies may reduce the risk of postoperative cognitive dysfunction in elderly patients.Zhipeng XuYuanlin DongHui WangDeborah J CulleyEdward R MarcantonioGregory CrosbyRudolph E TanziYiying ZhangZhongcong XiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96752 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhipeng Xu Yuanlin Dong Hui Wang Deborah J Culley Edward R Marcantonio Gregory Crosby Rudolph E Tanzi Yiying Zhang Zhongcong Xie Peripheral surgical wounding and age-dependent neuroinflammation in mice.
description	Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to contribute to cognitive dysfunction in humans and cognitive impairment in animals. Our recent studies have established a pre-clinical model in mice, and have found that the peripheral surgical wounding without the influence of general anesthesia induces an age-dependent Aβ accumulation and cognitive impairment in mice. We therefore set out to assess the effects of peripheral surgical wounding, in the absence of general anesthesia, on neuroinflammation in mice with different ages. Abdominal surgery under local anesthesia was established in 9 and 18 month-old mice. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), Iba1 positive cells (the marker of microglia activation), CD33, and cognitive function in mice were determined. The peripheral surgical wounding increased the levels of TNF-α, IL-6, and Iba1 positive cells in the hippocampus of both 9 and 18 month-old mice, and age potentiated these effects. The peripheral surgical wounding increased the levels of CD33 in the hippocampus of 18, but not 9, month-old mice. Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice. These data suggested that the peripheral surgical wounding could induce an age-dependent neuroinflammation and elevation of CD33 levels in the hippocampus of mice, which could lead to cognitive impairment in aged mice. Pending further studies, anti-inflammatory therapies may reduce the risk of postoperative cognitive dysfunction in elderly patients.
format	article
author	Zhipeng Xu Yuanlin Dong Hui Wang Deborah J Culley Edward R Marcantonio Gregory Crosby Rudolph E Tanzi Yiying Zhang Zhongcong Xie
author_facet	Zhipeng Xu Yuanlin Dong Hui Wang Deborah J Culley Edward R Marcantonio Gregory Crosby Rudolph E Tanzi Yiying Zhang Zhongcong Xie
author_sort	Zhipeng Xu
title	Peripheral surgical wounding and age-dependent neuroinflammation in mice.
title_short	Peripheral surgical wounding and age-dependent neuroinflammation in mice.
title_full	Peripheral surgical wounding and age-dependent neuroinflammation in mice.
title_fullStr	Peripheral surgical wounding and age-dependent neuroinflammation in mice.
title_full_unstemmed	Peripheral surgical wounding and age-dependent neuroinflammation in mice.
title_sort	peripheral surgical wounding and age-dependent neuroinflammation in mice.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/084fbe7d7577401bb310bf808e3fd482
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Peripheral surgical wounding and age-dependent neuroinflammation in mice.

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