Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women

Background and Aims: Studies of both animals and humans show that a high intake of vitamin A is associated with a lower risk of dyslipidemia. However, an association of plasma retinol levels with dyslipidemia is unclear. Therefore, the aim of this study is to investigate an association between plasm...

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Autores principales:	Ninglin Wang, Yuan Ru, Zhiying Yang, Changxuan Sun, Shanshan Li, Yan Min, Xueyin Zhao, Ying Lu, Ann W. Hsing, Shankuan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	vitamin A plasma retinol dyslipidemia metabolomics profiles pathway analysis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/08520a97e8c14dbeb6181f18fd9d6572
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spelling	oai:doaj.org-article:08520a97e8c14dbeb6181f18fd9d65722021-11-17T06:27:25ZMetabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women2296-861X10.3389/fnut.2021.740435https://doaj.org/article/08520a97e8c14dbeb6181f18fd9d65722021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.740435/fullhttps://doaj.org/toc/2296-861XBackground and Aims: Studies of both animals and humans show that a high intake of vitamin A is associated with a lower risk of dyslipidemia. However, an association of plasma retinol levels with dyslipidemia is unclear. Therefore, the aim of this study is to investigate an association between plasma retinol and dyslipidemia and to identify related metabolites and pathways in the general population.Methods: We included 250 participants aged 20–80 years from the Wellness Living Laboratory (WELL) China cohort. Associations between plasma retinol levels and dyslipidemia were analyzed using adjusted logistic models. Related metabolites were identified using ANCOVA, adjusted for the false discovery rate (FDR) and used for pathway analyses. Because there are sex differences in plasma retinol levels, all analyses were conducted separately by sex.Results: Plasma retinol was significantly higher in men than in women. A positive association between plasma retinol and dyslipidemia was found in both sexes. In men, the 2nd and 3rd tertiles showed significantly higher proportions of dyslipidemia than the 1st tertile (1st tertile vs. 2nd tertile: p = 0.026; 1st tertile vs. 3rd tertile: p = 0.003). In women, the 3rd tertile showed a significantly higher proportion of dyslipidemia than the 1st and 2nd tertile (3rd tertile vs. 1st tertile: p = 0.002, 3rd tertile vs. 2nd tertile: p = 0.002). Overall, 75 and 30 metabolites were significantly associated with retinol levels in men and women, respectively. According to these metabolites, lipid metabolic pathways, including glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and glycosylphosphatidylinositol (GPI), as well as steroid hormone biosynthesis pathways were found to overlap across the sexes. These pathways showed that elevated retinol levels might be associated with hormone metabolism and inflammation status.Conclusions: We found a positive association between plasma retinol levels and dyslipidemia. Related metabolomic profiles and interrupted pathways showed that such an increase might be associated with steroid hormone synthesis and inflammation. In addition, large, population-based longitudinal studies and intervention studies are needed to confirm the role of retinol in lipid metabolism and the prevention of cardiovascular disease (CVD).Ninglin WangNinglin WangYuan RuYuan RuZhiying YangZhiying YangChangxuan SunChangxuan SunShanshan LiShanshan LiYan MinXueyin ZhaoXueyin ZhaoYing LuAnn W. HsingAnn W. HsingAnn W. HsingShankuan ZhuShankuan ZhuFrontiers Media S.A.articlevitamin Aplasma retinoldyslipidemiametabolomics profilespathway analysisNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin A plasma retinol dyslipidemia metabolomics profiles pathway analysis Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin A plasma retinol dyslipidemia metabolomics profiles pathway analysis Nutrition. Foods and food supply TX341-641 Ninglin Wang Ninglin Wang Yuan Ru Yuan Ru Zhiying Yang Zhiying Yang Changxuan Sun Changxuan Sun Shanshan Li Shanshan Li Yan Min Xueyin Zhao Xueyin Zhao Ying Lu Ann W. Hsing Ann W. Hsing Ann W. Hsing Shankuan Zhu Shankuan Zhu Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
description	Background and Aims: Studies of both animals and humans show that a high intake of vitamin A is associated with a lower risk of dyslipidemia. However, an association of plasma retinol levels with dyslipidemia is unclear. Therefore, the aim of this study is to investigate an association between plasma retinol and dyslipidemia and to identify related metabolites and pathways in the general population.Methods: We included 250 participants aged 20–80 years from the Wellness Living Laboratory (WELL) China cohort. Associations between plasma retinol levels and dyslipidemia were analyzed using adjusted logistic models. Related metabolites were identified using ANCOVA, adjusted for the false discovery rate (FDR) and used for pathway analyses. Because there are sex differences in plasma retinol levels, all analyses were conducted separately by sex.Results: Plasma retinol was significantly higher in men than in women. A positive association between plasma retinol and dyslipidemia was found in both sexes. In men, the 2nd and 3rd tertiles showed significantly higher proportions of dyslipidemia than the 1st tertile (1st tertile vs. 2nd tertile: p = 0.026; 1st tertile vs. 3rd tertile: p = 0.003). In women, the 3rd tertile showed a significantly higher proportion of dyslipidemia than the 1st and 2nd tertile (3rd tertile vs. 1st tertile: p = 0.002, 3rd tertile vs. 2nd tertile: p = 0.002). Overall, 75 and 30 metabolites were significantly associated with retinol levels in men and women, respectively. According to these metabolites, lipid metabolic pathways, including glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and glycosylphosphatidylinositol (GPI), as well as steroid hormone biosynthesis pathways were found to overlap across the sexes. These pathways showed that elevated retinol levels might be associated with hormone metabolism and inflammation status.Conclusions: We found a positive association between plasma retinol levels and dyslipidemia. Related metabolomic profiles and interrupted pathways showed that such an increase might be associated with steroid hormone synthesis and inflammation. In addition, large, population-based longitudinal studies and intervention studies are needed to confirm the role of retinol in lipid metabolism and the prevention of cardiovascular disease (CVD).
format	article
author	Ninglin Wang Ninglin Wang Yuan Ru Yuan Ru Zhiying Yang Zhiying Yang Changxuan Sun Changxuan Sun Shanshan Li Shanshan Li Yan Min Xueyin Zhao Xueyin Zhao Ying Lu Ann W. Hsing Ann W. Hsing Ann W. Hsing Shankuan Zhu Shankuan Zhu
author_facet	Ninglin Wang Ninglin Wang Yuan Ru Yuan Ru Zhiying Yang Zhiying Yang Changxuan Sun Changxuan Sun Shanshan Li Shanshan Li Yan Min Xueyin Zhao Xueyin Zhao Ying Lu Ann W. Hsing Ann W. Hsing Ann W. Hsing Shankuan Zhu Shankuan Zhu
author_sort	Ninglin Wang
title	Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
title_short	Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
title_full	Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
title_fullStr	Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
title_full_unstemmed	Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women
title_sort	metabolomic profiles of plasma retinol-associated dyslipidemia in men and women
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/08520a97e8c14dbeb6181f18fd9d6572
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Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women

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