Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ub...

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Autores principales: Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b208
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spelling oai:doaj.org-article:08531e386b7c4c13a7c8af733ca4b2082021-12-02T14:41:20ZNur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation10.1038/ncomms144202041-1723https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b2082017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14420https://doaj.org/toc/2041-1723Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ubc9.Xue-li BianHang-zi ChenPeng-bo YangYing-ping LiFen-na ZhangJia-yuan ZhangWei-jia WangWen-xiu ZhaoSheng ZhangQi-tao ChenYu ZhengXiao-yu SunXiao-min WangKun-Yi ChienQiao WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xue-li Bian
Hang-zi Chen
Peng-bo Yang
Ying-ping Li
Fen-na Zhang
Jia-yuan Zhang
Wei-jia Wang
Wen-xiu Zhao
Sheng Zhang
Qi-tao Chen
Yu Zheng
Xiao-yu Sun
Xiao-min Wang
Kun-Yi Chien
Qiao Wu
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
description Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ubc9.
format article
author Xue-li Bian
Hang-zi Chen
Peng-bo Yang
Ying-ping Li
Fen-na Zhang
Jia-yuan Zhang
Wei-jia Wang
Wen-xiu Zhao
Sheng Zhang
Qi-tao Chen
Yu Zheng
Xiao-yu Sun
Xiao-min Wang
Kun-Yi Chien
Qiao Wu
author_facet Xue-li Bian
Hang-zi Chen
Peng-bo Yang
Ying-ping Li
Fen-na Zhang
Jia-yuan Zhang
Wei-jia Wang
Wen-xiu Zhao
Sheng Zhang
Qi-tao Chen
Yu Zheng
Xiao-yu Sun
Xiao-min Wang
Kun-Yi Chien
Qiao Wu
author_sort Xue-li Bian
title Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
title_short Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
title_full Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
title_fullStr Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
title_full_unstemmed Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
title_sort nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b208
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AT hangzichen nur77suppresseshepatocellularcarcinomaviaswitchingglucosemetabolismtowardgluconeogenesisthroughattenuatingphosphoenolpyruvatecarboxykinasesumoylation
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AT xiaominwang nur77suppresseshepatocellularcarcinomaviaswitchingglucosemetabolismtowardgluconeogenesisthroughattenuatingphosphoenolpyruvatecarboxykinasesumoylation
AT kunyichien nur77suppresseshepatocellularcarcinomaviaswitchingglucosemetabolismtowardgluconeogenesisthroughattenuatingphosphoenolpyruvatecarboxykinasesumoylation
AT qiaowu nur77suppresseshepatocellularcarcinomaviaswitchingglucosemetabolismtowardgluconeogenesisthroughattenuatingphosphoenolpyruvatecarboxykinasesumoylation
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