Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ub...
Guardado en:
Autores principales: | Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b208 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The Role of Tyrosine 207 in the Reaction Catalyzed by Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase
por: Andrade,Cherie, et al.
Publicado: (2010) -
Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release.
por: Anne-Marie Jaubert, et al.
Publicado: (2012) -
Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
por: Boning Niu, et al.
Publicado: (2021) -
Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
por: Sonia Perez-Sieira, et al.
Publicado: (2013) -
The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells
por: Madelaine C. Brearley, et al.
Publicado: (2020)