Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study

Abstract The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event...

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Autores principales:	Adrià Vilà-Balló, Clément François, David Cucurell, Júlia Miró, Mercè Falip, Montserrat Juncadella, Antoni Rodríguez-Fornells
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0858ca3047704a3c8b28ed2d5281e07f
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spelling	oai:doaj.org-article:0858ca3047704a3c8b28ed2d5281e07f2021-12-02T12:32:58ZAuditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study10.1038/s41598-017-01531-82045-2322https://doaj.org/article/0858ca3047704a3c8b28ed2d5281e07f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01531-8https://doaj.org/toc/2045-2322Abstract The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of patients had a focal unilateral damage restricted to the hippocampus and especially its medial part. We found a clear deficit for target processing at the behavioral level. In addition, compared to controls, our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved in the detection of novel and target stimuli.Adrià Vilà-BallóClément FrançoisDavid CucurellJúlia MiróMercè FalipMontserrat JuncadellaAntoni Rodríguez-FornellsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adrià Vilà-Balló Clément François David Cucurell Júlia Miró Mercè Falip Montserrat Juncadella Antoni Rodríguez-Fornells Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
description	Abstract The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of patients had a focal unilateral damage restricted to the hippocampus and especially its medial part. We found a clear deficit for target processing at the behavioral level. In addition, compared to controls, our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved in the detection of novel and target stimuli.
format	article
author	Adrià Vilà-Balló Clément François David Cucurell Júlia Miró Mercè Falip Montserrat Juncadella Antoni Rodríguez-Fornells
author_facet	Adrià Vilà-Balló Clément François David Cucurell Júlia Miró Mercè Falip Montserrat Juncadella Antoni Rodríguez-Fornells
author_sort	Adrià Vilà-Balló
title	Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
title_short	Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
title_full	Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
title_fullStr	Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
title_full_unstemmed	Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
title_sort	auditory target and novelty processing in patients with unilateral hippocampal sclerosis: a current-source density study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0858ca3047704a3c8b28ed2d5281e07f
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Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study

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