Dynamic effective connectivity of inter-areal brain circuits.

Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity (or, more precisely, causal connectivity), related to the elusive question &quo...

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Autores principales:	Demian Battaglia, Annette Witt, Fred Wolf, Theo Geisel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/08596fac2051456481671590a915fab6
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spelling	oai:doaj.org-article:08596fac2051456481671590a915fab62021-11-18T05:51:28ZDynamic effective connectivity of inter-areal brain circuits.1553-734X1553-735810.1371/journal.pcbi.1002438https://doaj.org/article/08596fac2051456481671590a915fab62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457614/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity (or, more precisely, causal connectivity), related to the elusive question "Which areas cause the present activity of which others?". Effective connectivity is directed and depends flexibly on contexts and tasks. Here we show that dynamic effective connectivity can emerge from transitions in the collective organization of coherent neural activity. Integrating simulation and semi-analytic approaches, we study mesoscale network motifs of interacting cortical areas, modeled as large random networks of spiking neurons or as simple rate units. Through a causal analysis of time-series of model neural activity, we show that different dynamical states generated by a same structural connectivity motif correspond to distinct effective connectivity motifs. Such effective motifs can display a dominant directionality, due to spontaneous symmetry breaking and effective entrainment between local brain rhythms, although all connections in the considered structural motifs are reciprocal. We show then that transitions between effective connectivity configurations (like, for instance, reversal in the direction of inter-areal interactions) can be triggered reliably by brief perturbation inputs, properly timed with respect to an ongoing local oscillation, without the need for plastic synaptic changes. Finally, we analyze how the information encoded in spiking patterns of a local neuronal population is propagated across a fixed structural connectivity motif, demonstrating that changes in the active effective connectivity regulate both the efficiency and the directionality of information transfer. Previous studies stressed the role played by coherent oscillations in establishing efficient communication between distant areas. Going beyond these early proposals, we advance here that dynamic interactions between brain rhythms provide as well the basis for the self-organized control of this "communication-through-coherence", making thus possible a fast "on-demand" reconfiguration of global information routing modalities.Demian BattagliaAnnette WittFred WolfTheo GeiselPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 3, p e1002438 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Demian Battaglia Annette Witt Fred Wolf Theo Geisel Dynamic effective connectivity of inter-areal brain circuits.
description	Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity (or, more precisely, causal connectivity), related to the elusive question "Which areas cause the present activity of which others?". Effective connectivity is directed and depends flexibly on contexts and tasks. Here we show that dynamic effective connectivity can emerge from transitions in the collective organization of coherent neural activity. Integrating simulation and semi-analytic approaches, we study mesoscale network motifs of interacting cortical areas, modeled as large random networks of spiking neurons or as simple rate units. Through a causal analysis of time-series of model neural activity, we show that different dynamical states generated by a same structural connectivity motif correspond to distinct effective connectivity motifs. Such effective motifs can display a dominant directionality, due to spontaneous symmetry breaking and effective entrainment between local brain rhythms, although all connections in the considered structural motifs are reciprocal. We show then that transitions between effective connectivity configurations (like, for instance, reversal in the direction of inter-areal interactions) can be triggered reliably by brief perturbation inputs, properly timed with respect to an ongoing local oscillation, without the need for plastic synaptic changes. Finally, we analyze how the information encoded in spiking patterns of a local neuronal population is propagated across a fixed structural connectivity motif, demonstrating that changes in the active effective connectivity regulate both the efficiency and the directionality of information transfer. Previous studies stressed the role played by coherent oscillations in establishing efficient communication between distant areas. Going beyond these early proposals, we advance here that dynamic interactions between brain rhythms provide as well the basis for the self-organized control of this "communication-through-coherence", making thus possible a fast "on-demand" reconfiguration of global information routing modalities.
format	article
author	Demian Battaglia Annette Witt Fred Wolf Theo Geisel
author_facet	Demian Battaglia Annette Witt Fred Wolf Theo Geisel
author_sort	Demian Battaglia
title	Dynamic effective connectivity of inter-areal brain circuits.
title_short	Dynamic effective connectivity of inter-areal brain circuits.
title_full	Dynamic effective connectivity of inter-areal brain circuits.
title_fullStr	Dynamic effective connectivity of inter-areal brain circuits.
title_full_unstemmed	Dynamic effective connectivity of inter-areal brain circuits.
title_sort	dynamic effective connectivity of inter-areal brain circuits.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/08596fac2051456481671590a915fab6
work_keys_str_mv	AT demianbattaglia dynamiceffectiveconnectivityofinterarealbraincircuits AT annettewitt dynamiceffectiveconnectivityofinterarealbraincircuits AT fredwolf dynamiceffectiveconnectivityofinterarealbraincircuits AT theogeisel dynamiceffectiveconnectivityofinterarealbraincircuits
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Dynamic effective connectivity of inter-areal brain circuits.

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