Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications

Huinan Liu, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: Ceramic/polymer composites have been considered as third-generation orthopedic biomaterials due to their ability to closely match properties (such as surface, chemistry, biological, and mechanical) of...

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Autores principales:	Huinan Liu, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/085aac93df074de99ad9018426d52b34
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spelling	oai:doaj.org-article:085aac93df074de99ad9018426d52b342021-12-02T02:53:08ZMechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications1176-91141178-2013https://doaj.org/article/085aac93df074de99ad9018426d52b342010-04-01T00:00:00Zhttp://www.dovepress.com/mechanical-properties-of-dispersed-ceramic-nanoparticles-in-polymer-co-a4234https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Huinan Liu, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: Ceramic/polymer composites have been considered as third-generation orthopedic biomaterials due to their ability to closely match properties (such as surface, chemistry, biological, and mechanical) of natural bone. It has already been shown that the addition of nanophase compared with conventional (or micron-scale) ceramics to polymers enhances bone cell functions. However, in order to fully take advantage of the promising nanometer size effects that nanoceramics can provide when added to polymers, it is critical to uniformly disperse them in a polymer matrix. This is critical since ceramic nanoparticles inherently have a strong tendency to form larger agglomerates in a polymer matrix which may compromise their properties. Therefore, in this study, model ceramic nanoparticles, specifically titania and hydroxyapatite (HA), were dispersed in a model polymer (PLGA, poly-lactic-co-glycolic acid) using high-power ultrasonic energy. The mechanical properties of the resulting PLGA composites with well-dispersed ceramic (either titania or HA) nanoparticles were investigated and compared with composites with agglomerated ceramic nanoparticles. Results demonstrated that well-dispersed ceramic nanoparticles (titania or HA) in PLGA improved mechanical properties compared with agglomerated ceramic nanoparticles even though the weight percentage of the ceramics was the same. Specifically, well-dispersed nanoceramics in PLGA enhanced the tensile modulus, tensile strength at yield, ultimate tensile strength, and compressive modulus compared with the more agglomerated nanoceramics in PLGA. In summary, supplemented by previous studies that demonstrated greater osteoblast (bone-forming cell) functions on well-dispersed nanophase ceramics in polymers, the present study demonstrated that the combination of PLGA with well-dispersed nanoceramics enhanced mechanical properties necessary for load-bearing orthopedic/dental applications.Keywords: nanocomposites, ceramic nanoparticles, titania nanoparticles, hydroxyapatite nanoparticles, dispersion, agglomeration, biodegradable polymer, PLGA, mechanical properties, orthopedic/dental applications Huinan LiuThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 299-313 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Huinan Liu Thomas J Webster Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
description	Huinan Liu, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: Ceramic/polymer composites have been considered as third-generation orthopedic biomaterials due to their ability to closely match properties (such as surface, chemistry, biological, and mechanical) of natural bone. It has already been shown that the addition of nanophase compared with conventional (or micron-scale) ceramics to polymers enhances bone cell functions. However, in order to fully take advantage of the promising nanometer size effects that nanoceramics can provide when added to polymers, it is critical to uniformly disperse them in a polymer matrix. This is critical since ceramic nanoparticles inherently have a strong tendency to form larger agglomerates in a polymer matrix which may compromise their properties. Therefore, in this study, model ceramic nanoparticles, specifically titania and hydroxyapatite (HA), were dispersed in a model polymer (PLGA, poly-lactic-co-glycolic acid) using high-power ultrasonic energy. The mechanical properties of the resulting PLGA composites with well-dispersed ceramic (either titania or HA) nanoparticles were investigated and compared with composites with agglomerated ceramic nanoparticles. Results demonstrated that well-dispersed ceramic nanoparticles (titania or HA) in PLGA improved mechanical properties compared with agglomerated ceramic nanoparticles even though the weight percentage of the ceramics was the same. Specifically, well-dispersed nanoceramics in PLGA enhanced the tensile modulus, tensile strength at yield, ultimate tensile strength, and compressive modulus compared with the more agglomerated nanoceramics in PLGA. In summary, supplemented by previous studies that demonstrated greater osteoblast (bone-forming cell) functions on well-dispersed nanophase ceramics in polymers, the present study demonstrated that the combination of PLGA with well-dispersed nanoceramics enhanced mechanical properties necessary for load-bearing orthopedic/dental applications.Keywords: nanocomposites, ceramic nanoparticles, titania nanoparticles, hydroxyapatite nanoparticles, dispersion, agglomeration, biodegradable polymer, PLGA, mechanical properties, orthopedic/dental applications
format	article
author	Huinan Liu Thomas J Webster
author_facet	Huinan Liu Thomas J Webster
author_sort	Huinan Liu
title	Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
title_short	Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
title_full	Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
title_fullStr	Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
title_full_unstemmed	Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
title_sort	mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/085aac93df074de99ad9018426d52b34
work_keys_str_mv	AT huinanliu mechanicalpropertiesofdispersedceramicnanoparticlesinpolymercompositesfororthopedicapplications AT thomasjwebster mechanicalpropertiesofdispersedceramicnanoparticlesinpolymercompositesfororthopedicapplications
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Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications

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