Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder

Abstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced osci...

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Autores principales:	Paul A. Schauer, Jonas Rauh, Sarah V. Biedermann, Moritz Haaf, Saskia Steinmann, Gregor Leicht, Christoph Mulert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0860e531bc0b461da5b56d12d4593458
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spelling	oai:doaj.org-article:0860e531bc0b461da5b56d12d45934582021-12-02T16:37:37ZSimultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder10.1038/s41598-021-96209-72045-2322https://doaj.org/article/0860e531bc0b461da5b56d12d45934582021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96209-7https://doaj.org/toc/2045-2322Abstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences.Paul A. SchauerJonas RauhSarah V. BiedermannMoritz HaafSaskia SteinmannGregor LeichtChristoph MulertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
description	Abstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences.
format	article
author	Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert
author_facet	Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert
author_sort	Paul A. Schauer
title	Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
title_short	Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
title_full	Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
title_fullStr	Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
title_full_unstemmed	Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
title_sort	simultaneous eeg-fmri reveals theta network alterations during reward feedback processing in borderline personality disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0860e531bc0b461da5b56d12d4593458
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Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder

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