Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.

Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative compone...

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Autores principales:	Jean-Baptiste Passot, Denis Sheynikhovich, Éléonore Duvelle, Angelo Arleo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08610c69dcee4b3cb6387879ba169d15
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spelling	oai:doaj.org-article:08610c69dcee4b3cb6387879ba169d152021-11-18T07:23:31ZContribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.1932-620310.1371/journal.pone.0032560https://doaj.org/article/08610c69dcee4b3cb6387879ba169d152012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22485133/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation.Jean-Baptiste PassotDenis SheynikhovichÉléonore DuvelleAngelo ArleoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e32560 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-Baptiste Passot Denis Sheynikhovich Éléonore Duvelle Angelo Arleo Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
description	Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation.
format	article
author	Jean-Baptiste Passot Denis Sheynikhovich Éléonore Duvelle Angelo Arleo
author_facet	Jean-Baptiste Passot Denis Sheynikhovich Éléonore Duvelle Angelo Arleo
author_sort	Jean-Baptiste Passot
title	Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
title_short	Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
title_full	Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
title_fullStr	Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
title_full_unstemmed	Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
title_sort	contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/08610c69dcee4b3cb6387879ba169d15
work_keys_str_mv	AT jeanbaptistepassot contributionofcerebellarsensorimotoradaptationtohippocampalspatialmemory AT denissheynikhovich contributionofcerebellarsensorimotoradaptationtohippocampalspatialmemory AT eleonoreduvelle contributionofcerebellarsensorimotoradaptationtohippocampalspatialmemory AT angeloarleo contributionofcerebellarsensorimotoradaptationtohippocampalspatialmemory
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Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.

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