Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial function.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alessio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastian Monasor, Martina Schifferer, Ludovico Cantuti-Castelvetri, Jasmin König, Lea Vidatic, Tatiana Bremova-Ertl, Andrew P. Lieberman, Silva Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Strupp, Susanne A. Schneider, Sabina Tahirovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/086477f8dbac4c818ed45236ab495029
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:086477f8dbac4c818ed45236ab495029
record_format	dspace
spelling	oai:doaj.org-article:086477f8dbac4c818ed45236ab4950292021-12-02T13:14:59ZLoss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia10.1038/s41467-021-21428-52041-1723https://doaj.org/article/086477f8dbac4c818ed45236ab4950292021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21428-5https://doaj.org/toc/2041-1723Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial function.Alessio ColomboLina DinkelStephan A. MüllerLaura Sebastian MonasorMartina SchiffererLudovico Cantuti-CastelvetriJasmin KönigLea VidaticTatiana Bremova-ErtlAndrew P. LiebermanSilva HecimovicMikael SimonsStefan F. LichtenthalerMichael StruppSusanne A. SchneiderSabina TahirovicNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessio Colombo Lina Dinkel Stephan A. Müller Laura Sebastian Monasor Martina Schifferer Ludovico Cantuti-Castelvetri Jasmin König Lea Vidatic Tatiana Bremova-Ertl Andrew P. Lieberman Silva Hecimovic Mikael Simons Stefan F. Lichtenthaler Michael Strupp Susanne A. Schneider Sabina Tahirovic Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
description	Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial function.
format	article
author	Alessio Colombo Lina Dinkel Stephan A. Müller Laura Sebastian Monasor Martina Schifferer Ludovico Cantuti-Castelvetri Jasmin König Lea Vidatic Tatiana Bremova-Ertl Andrew P. Lieberman Silva Hecimovic Mikael Simons Stefan F. Lichtenthaler Michael Strupp Susanne A. Schneider Sabina Tahirovic
author_facet	Alessio Colombo Lina Dinkel Stephan A. Müller Laura Sebastian Monasor Martina Schifferer Ludovico Cantuti-Castelvetri Jasmin König Lea Vidatic Tatiana Bremova-Ertl Andrew P. Lieberman Silva Hecimovic Mikael Simons Stefan F. Lichtenthaler Michael Strupp Susanne A. Schneider Sabina Tahirovic
author_sort	Alessio Colombo
title	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
title_short	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
title_full	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
title_fullStr	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
title_full_unstemmed	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
title_sort	loss of npc1 enhances phagocytic uptake and impairs lipid trafficking in microglia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/086477f8dbac4c818ed45236ab495029
work_keys_str_mv	AT alessiocolombo lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT linadinkel lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT stephanamuller lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT laurasebastianmonasor lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT martinaschifferer lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT ludovicocantuticastelvetri lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT jasminkonig lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT leavidatic lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT tatianabremovaertl lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT andrewplieberman lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT silvahecimovic lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT mikaelsimons lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT stefanflichtenthaler lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT michaelstrupp lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT susanneaschneider lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia AT sabinatahirovic lossofnpc1enhancesphagocyticuptakeandimpairslipidtraffickinginmicroglia
_version_	1718393370731085824

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Ejemplares similares