The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia

It is well known that much pathology observed immediately after birth or in later periods of postnatal life is associated with adverse prenatal development. The mechanisms of this phenomenon, however, warrant further investigation. Accordingly, the aim of the present study was to compare oxidative d...

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Autores principales:	Y. P. Milyutina, A. V. Pustygina, A. D. Spcherbitskaya, I. V. Zaloznyaya, A. V. Arutyunyan
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	hyperhomocysteinemia oxidative stress superoxide dismutase Science Q
Acceso en línea:	https://doaj.org/article/0866f74e89b34e5faeaaf5259bfc3a52
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spelling	oai:doaj.org-article:0866f74e89b34e5faeaaf5259bfc3a522021-11-23T06:14:34ZThe comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia2541-94202587-959610.12737/article_590823a4e61655.66153600https://doaj.org/article/0866f74e89b34e5faeaaf5259bfc3a522016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/202https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596It is well known that much pathology observed immediately after birth or in later periods of postnatal life is associated with adverse prenatal development. The mechanisms of this phenomenon, however, warrant further investigation. Accordingly, the aim of the present study was to compare oxidative damage caused to macromolecules, especially proteins and nucleic acids, and to assess the state of the antioxidant system in rats with chronically elevated blood plasma L-homocysteine (Hcy), as well as in their offsprings exposed to hyperhomocysteinemia (HHcy) throughout pregnancy. It was shown that blood Hcy was elevated in both studied models, but in the rats with past HHcy, it returned back to normal values in two months of postnatal life. Both alimentary and prenatal HHcy increased nitrotyrosine production and changed the activity of superoxide dismutase in the experimental animals and their matured offspring. The high activity of the enzyme in late periods found in animals that underwent prenatal HHcy gave indirect evidence to hypergeneration of superoxide radical. Despite the restored level of Hcy, free radical oxidation activation was observed in the rats, whose mothers had been administered with L-methionine throughout pregnancy, which was confirmed by elevated blood serum nitrotyrosine. The data obtained were concordant with the idea that the elevated blood plasma Hcy found in pregnant rats resulted in oxidative stress developed in their offsprings, which manifested itself months later on their postnatal life.Y. P. MilyutinaA. V. PustyginaA. D. SpcherbitskayaI. V. ZaloznyayaA. V. ArutyunyanScientific Сentre for Family Health and Human Reproduction Problemsarticlehyperhomocysteinemiaoxidative stresssuperoxide dismutaseScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 120-123 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	hyperhomocysteinemia oxidative stress superoxide dismutase Science Q
spellingShingle	hyperhomocysteinemia oxidative stress superoxide dismutase Science Q Y. P. Milyutina A. V. Pustygina A. D. Spcherbitskaya I. V. Zaloznyaya A. V. Arutyunyan The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
description	It is well known that much pathology observed immediately after birth or in later periods of postnatal life is associated with adverse prenatal development. The mechanisms of this phenomenon, however, warrant further investigation. Accordingly, the aim of the present study was to compare oxidative damage caused to macromolecules, especially proteins and nucleic acids, and to assess the state of the antioxidant system in rats with chronically elevated blood plasma L-homocysteine (Hcy), as well as in their offsprings exposed to hyperhomocysteinemia (HHcy) throughout pregnancy. It was shown that blood Hcy was elevated in both studied models, but in the rats with past HHcy, it returned back to normal values in two months of postnatal life. Both alimentary and prenatal HHcy increased nitrotyrosine production and changed the activity of superoxide dismutase in the experimental animals and their matured offspring. The high activity of the enzyme in late periods found in animals that underwent prenatal HHcy gave indirect evidence to hypergeneration of superoxide radical. Despite the restored level of Hcy, free radical oxidation activation was observed in the rats, whose mothers had been administered with L-methionine throughout pregnancy, which was confirmed by elevated blood serum nitrotyrosine. The data obtained were concordant with the idea that the elevated blood plasma Hcy found in pregnant rats resulted in oxidative stress developed in their offsprings, which manifested itself months later on their postnatal life.
format	article
author	Y. P. Milyutina A. V. Pustygina A. D. Spcherbitskaya I. V. Zaloznyaya A. V. Arutyunyan
author_facet	Y. P. Milyutina A. V. Pustygina A. D. Spcherbitskaya I. V. Zaloznyaya A. V. Arutyunyan
author_sort	Y. P. Milyutina
title	The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
title_short	The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
title_full	The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
title_fullStr	The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
title_full_unstemmed	The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
title_sort	comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/0866f74e89b34e5faeaaf5259bfc3a52
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The comparison of oxidative stress profiles in rat blood serum in different experimental models of hyperhomo-cysteinemia

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