Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.

<h4>Background</h4>Liver fatty acid-binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.<h4>Methodology and principal findings</h4>...

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Autores principales:	Juan Shi, Yifei Zhang, Weiqiong Gu, Bin Cui, Min Xu, Qun Yan, Weiqing Wang, Guang Ning, Jie Hong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0869772c64cf40bf8e5441360bcbbcfd
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spelling	oai:doaj.org-article:0869772c64cf40bf8e5441360bcbbcfd2021-11-18T08:09:40ZSerum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.1932-620310.1371/journal.pone.0048777https://doaj.org/article/0869772c64cf40bf8e5441360bcbbcfd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144966/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Liver fatty acid-binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.<h4>Methodology and principal findings</h4>Cross-sectional analysis including 200 obese and 172 normal-weight subjects matched for age and sex, anthropometric measurements were performed and serum FABP1 and biochemical characteristics were measured. Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR) and by the insulin sensitivity index (S(i)) derived from Bergman's minimal model. FABP1 levels in obese subjects were significantly higher than those in normal-weight subjects (p<0.001) and the significance remained after adjustment for age, gender, alanine and aspartate aminotransferases (p<0.001). Serum FABP1 levels were significantly correlated with many metabolic-related parameters, with BMI and triglycerides as the independent determinants. FABP1 levels remained an independent risk factor of insulin resistance assessed by binary S(i) (OR = 1.868 per SD unit, 95% CI [1.035-3.373], p = 0.038) after adjustment for age, sex, BMI, waist circumference, systolic blood pressure, serum triacylglycerol, total cholesterol, HDL- and LDL-cholesterol,. FABP1 levels were also elevated with an increasing number of components of the metabolic syndrome (p for trend <0.001). Multiple regression modeling for the MetS and its components demonstrated that hypertriglyceridemia and low HDL-cholesterol were significantly correlated to serum FABP1 levels.<h4>Conclusions and significance</h4>Serum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults. Our data supports the fact that FABP1 might be an important mediator participating in fatty acid metabolism and energy balance.Juan ShiYifei ZhangWeiqiong GuBin CuiMin XuQun YanWeiqing WangGuang NingJie HongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48777 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Shi Yifei Zhang Weiqiong Gu Bin Cui Min Xu Qun Yan Weiqing Wang Guang Ning Jie Hong Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
description	<h4>Background</h4>Liver fatty acid-binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.<h4>Methodology and principal findings</h4>Cross-sectional analysis including 200 obese and 172 normal-weight subjects matched for age and sex, anthropometric measurements were performed and serum FABP1 and biochemical characteristics were measured. Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR) and by the insulin sensitivity index (S(i)) derived from Bergman's minimal model. FABP1 levels in obese subjects were significantly higher than those in normal-weight subjects (p<0.001) and the significance remained after adjustment for age, gender, alanine and aspartate aminotransferases (p<0.001). Serum FABP1 levels were significantly correlated with many metabolic-related parameters, with BMI and triglycerides as the independent determinants. FABP1 levels remained an independent risk factor of insulin resistance assessed by binary S(i) (OR = 1.868 per SD unit, 95% CI [1.035-3.373], p = 0.038) after adjustment for age, sex, BMI, waist circumference, systolic blood pressure, serum triacylglycerol, total cholesterol, HDL- and LDL-cholesterol,. FABP1 levels were also elevated with an increasing number of components of the metabolic syndrome (p for trend <0.001). Multiple regression modeling for the MetS and its components demonstrated that hypertriglyceridemia and low HDL-cholesterol were significantly correlated to serum FABP1 levels.<h4>Conclusions and significance</h4>Serum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults. Our data supports the fact that FABP1 might be an important mediator participating in fatty acid metabolism and energy balance.
format	article
author	Juan Shi Yifei Zhang Weiqiong Gu Bin Cui Min Xu Qun Yan Weiqing Wang Guang Ning Jie Hong
author_facet	Juan Shi Yifei Zhang Weiqiong Gu Bin Cui Min Xu Qun Yan Weiqing Wang Guang Ning Jie Hong
author_sort	Juan Shi
title	Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
title_short	Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
title_full	Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
title_fullStr	Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
title_full_unstemmed	Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
title_sort	serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in chinese young adults.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0869772c64cf40bf8e5441360bcbbcfd
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Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.

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