Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis

Endogenous uveitis (EU) in children is a multifactorial sight-threatening disease that reduces patient’s quality of life. Proliferative syndrome (PS) coupled to developing adhesions, opacity of vitreous body, epiretinal and preretinal membranes is one of the most serious EU complications, with yet-u...

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Autores principales:	M. S. Petrovskaya, G. I. Krichevskaya, E. V. Denisova, L. A. Katargina, I. G. Kulikova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	epstein–barr virus uveitis proliferative syndrome il-6 il-8 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/086b0b50bd8f4d38a3239a6add0ed64c
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spelling	oai:doaj.org-article:086b0b50bd8f4d38a3239a6add0ed64c2021-11-22T07:09:53ZImportance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis2220-76192313-739810.15789/2220-7619-2019-5-6-800-804https://doaj.org/article/086b0b50bd8f4d38a3239a6add0ed64c2020-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/719https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Endogenous uveitis (EU) in children is a multifactorial sight-threatening disease that reduces patient’s quality of life. Proliferative syndrome (PS) coupled to developing adhesions, opacity of vitreous body, epiretinal and preretinal membranes is one of the most serious EU complications, with yet-unknown pathogenesis. Among the numerous trigger factors, a role for infections, particularly human herpes group-driven, is proposed. The goal of the study was to assess a potential role of Herpes simplex viruses type 1 (HSV-1), Herpes simplex viruses type 2 (HSV-2), Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) played in the PS pathogenesis in children with endogenous uveitis. 112 patients aged 3–17 years (mean age 10 years) with (93 patients)/without PS (19 children) were examined. IgM and IgG antibodies (markers of chronic and active infection) against HSV-1/2, EBV and CMV were detected by ELISA. A significantly increased PS rate in infected vs. uninfected children was revealed solely for EBV infection (p = 0.03), but not for HSV-1/2 (p > 0.05) or CMV-positive patients (p > 0.05). However, PS emergence in EBV-negative patients also suggests that some factors might contribute to proliferation in intraocular inflammation. In addition, level of serum IL-8 and IL-6 were assessed by multiplex analysis in 28 children. It was found that IL-8 was detected in all patients, with great individual fluctuations (5.6–2743 pg/ml). Enhanced systemic IL-8 level tended to rise in patients with more prominent proliferation and serological markers of EBV reactivation. However, serum IL-6 was detected by about 2-fold less often reaching up to 55% cases (variation of individual indices 1.3–35.5 pg/ml). A correlation between PS severity, EBV infection activity and systemic IL-6 level was not observed. Further studies evaluating a role of EBV infection in PS pathogenesis pediatric endogenous uveitis are necessary, as it may underlie a rationale for including antiherpetic drugs into a combination therapy.M. S. PetrovskayaG. I. KrichevskayaE. V. DenisovaL. A. KatarginaI. G. KulikovaSankt-Peterburg : NIIÈM imeni Pasteraarticleepstein–barr virusuveitisproliferative syndromeil-6il-8Infectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 5-6, Pp 800-804 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	epstein–barr virus uveitis proliferative syndrome il-6 il-8 Infectious and parasitic diseases RC109-216
spellingShingle	epstein–barr virus uveitis proliferative syndrome il-6 il-8 Infectious and parasitic diseases RC109-216 M. S. Petrovskaya G. I. Krichevskaya E. V. Denisova L. A. Katargina I. G. Kulikova Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
description	Endogenous uveitis (EU) in children is a multifactorial sight-threatening disease that reduces patient’s quality of life. Proliferative syndrome (PS) coupled to developing adhesions, opacity of vitreous body, epiretinal and preretinal membranes is one of the most serious EU complications, with yet-unknown pathogenesis. Among the numerous trigger factors, a role for infections, particularly human herpes group-driven, is proposed. The goal of the study was to assess a potential role of Herpes simplex viruses type 1 (HSV-1), Herpes simplex viruses type 2 (HSV-2), Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) played in the PS pathogenesis in children with endogenous uveitis. 112 patients aged 3–17 years (mean age 10 years) with (93 patients)/without PS (19 children) were examined. IgM and IgG antibodies (markers of chronic and active infection) against HSV-1/2, EBV and CMV were detected by ELISA. A significantly increased PS rate in infected vs. uninfected children was revealed solely for EBV infection (p = 0.03), but not for HSV-1/2 (p > 0.05) or CMV-positive patients (p > 0.05). However, PS emergence in EBV-negative patients also suggests that some factors might contribute to proliferation in intraocular inflammation. In addition, level of serum IL-8 and IL-6 were assessed by multiplex analysis in 28 children. It was found that IL-8 was detected in all patients, with great individual fluctuations (5.6–2743 pg/ml). Enhanced systemic IL-8 level tended to rise in patients with more prominent proliferation and serological markers of EBV reactivation. However, serum IL-6 was detected by about 2-fold less often reaching up to 55% cases (variation of individual indices 1.3–35.5 pg/ml). A correlation between PS severity, EBV infection activity and systemic IL-6 level was not observed. Further studies evaluating a role of EBV infection in PS pathogenesis pediatric endogenous uveitis are necessary, as it may underlie a rationale for including antiherpetic drugs into a combination therapy.
format	article
author	M. S. Petrovskaya G. I. Krichevskaya E. V. Denisova L. A. Katargina I. G. Kulikova
author_facet	M. S. Petrovskaya G. I. Krichevskaya E. V. Denisova L. A. Katargina I. G. Kulikova
author_sort	M. S. Petrovskaya
title	Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
title_short	Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
title_full	Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
title_fullStr	Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
title_full_unstemmed	Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
title_sort	importance of epstein–barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/086b0b50bd8f4d38a3239a6add0ed64c
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Importance of Epstein–Barr virus infection in pathogenesis of proliferative complications in children with endogenous uveitis

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