Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults

Lingli Cai,* Cheng Li,* Yufei Wang, Yifei Mo, Jun Yin, Xiaojing Ma Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus,...

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Autores principales:	Cai L, Li C, Wang Y, Mo Y, Yin J, Ma X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	growth differentiation factor 15 obesity metabolism low-carbohydrate diet exercise Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/086c9b0fd9e743829baff8381dccff06
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spelling	oai:doaj.org-article:086c9b0fd9e743829baff8381dccff062021-12-02T16:27:45ZIncreased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults1178-7007https://doaj.org/article/086c9b0fd9e743829baff8381dccff062021-03-01T00:00:00Zhttps://www.dovepress.com/increased-serum-gdf15-related-to-improvement-in-metabolism-by-lifestyl-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lingli Cai,* Cheng Li,* Yufei Wang, Yifei Mo, Jun Yin, Xiaojing Ma Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Yin; Xiaojing MaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of ChinaTel +86-21-64369181Fax +86-21-64368031Email yinjun@sjtu.edu.cn; maxiaojing@sjtu.edu.cnAim: Growth differentiation factor 15 (GDF15) is closely related to obesity. This study aimed to explore the influence of weight loss intervention on serum GDF15 levels and the relationship between GDF15 and metabolism.Materials and Methods: Forty-four overweight and obese adults either adopted a low-carbohydrate diet or performed moderate-to-vigorous exercise for 3 weeks. Weekly follow-ups were conducted to measure body composition, glucose and lipid metabolism and serum GDF15 levels.Results: After 3 weeks of intervention, body weight, fat mass and waist circumference in both groups decreased (P < 0.05). No significant change in GDF15 levels was observed in the two groups. Among all the subjects, 10 of them (22.7%, group of Down) showed a decrease in GDF15 and 34 (77.3%, group of Up) showed an increase in GDF15 after the intervention. We found that GDF15 increased significantly with the follow-up time in the UP group and waist circumference, fasting serum insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and triglycerides (TG) decreased (P for trend < 0.05). However, no significant differences in all parameters were detected in Down group. In addition, GDF15 was elevated between 30 mins and 120 mins in a 75-g oral glucose tolerance test. Its trend was negatively correlated with plasma glucose and serum insulin.Conclusion: Increased serum GDF15 was associated with improvement in metabolism by lifestyle intervention among young overweight and obese adults. The increase of GDF15 could be an indicator to evaluate metabolic improvements in overweight and obese people.Clinical Trial Registration: www.chictr.org.cn, registration number ChiCTR1800016786.Keywords: growth differentiation factor 15, obesity, metabolism, low-carbohydrate diet, exerciseCai LLi CWang YMo YYin JMa XDove Medical Pressarticlegrowth differentiation factor 15obesitymetabolismlow-carbohydrate dietexerciseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1195-1202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth differentiation factor 15 obesity metabolism low-carbohydrate diet exercise Specialties of internal medicine RC581-951
spellingShingle	growth differentiation factor 15 obesity metabolism low-carbohydrate diet exercise Specialties of internal medicine RC581-951 Cai L Li C Wang Y Mo Y Yin J Ma X Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
description	Lingli Cai,* Cheng Li,* Yufei Wang, Yifei Mo, Jun Yin, Xiaojing Ma Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Yin; Xiaojing MaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of ChinaTel +86-21-64369181Fax +86-21-64368031Email yinjun@sjtu.edu.cn; maxiaojing@sjtu.edu.cnAim: Growth differentiation factor 15 (GDF15) is closely related to obesity. This study aimed to explore the influence of weight loss intervention on serum GDF15 levels and the relationship between GDF15 and metabolism.Materials and Methods: Forty-four overweight and obese adults either adopted a low-carbohydrate diet or performed moderate-to-vigorous exercise for 3 weeks. Weekly follow-ups were conducted to measure body composition, glucose and lipid metabolism and serum GDF15 levels.Results: After 3 weeks of intervention, body weight, fat mass and waist circumference in both groups decreased (P < 0.05). No significant change in GDF15 levels was observed in the two groups. Among all the subjects, 10 of them (22.7%, group of Down) showed a decrease in GDF15 and 34 (77.3%, group of Up) showed an increase in GDF15 after the intervention. We found that GDF15 increased significantly with the follow-up time in the UP group and waist circumference, fasting serum insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and triglycerides (TG) decreased (P for trend < 0.05). However, no significant differences in all parameters were detected in Down group. In addition, GDF15 was elevated between 30 mins and 120 mins in a 75-g oral glucose tolerance test. Its trend was negatively correlated with plasma glucose and serum insulin.Conclusion: Increased serum GDF15 was associated with improvement in metabolism by lifestyle intervention among young overweight and obese adults. The increase of GDF15 could be an indicator to evaluate metabolic improvements in overweight and obese people.Clinical Trial Registration: www.chictr.org.cn, registration number ChiCTR1800016786.Keywords: growth differentiation factor 15, obesity, metabolism, low-carbohydrate diet, exercise
format	article
author	Cai L Li C Wang Y Mo Y Yin J Ma X
author_facet	Cai L Li C Wang Y Mo Y Yin J Ma X
author_sort	Cai L
title	Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
title_short	Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
title_full	Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
title_fullStr	Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
title_full_unstemmed	Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults
title_sort	increased serum gdf15 related to improvement in metabolism by lifestyle intervention among young overweight and obese adults
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/086c9b0fd9e743829baff8381dccff06
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Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults

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